ObjectiveTo summarize the mechanism of hydrogen sulfide (H2S) in regulating autophagy and ameliorating multi-organ dysfunction in the treatment of sepsis.MethodThe relevant literatures at home and abroad in recent years were systematically searched and read to review the mechanism of H2S in regulating autophagy and ameliorating multi-organ dysfunction during sepsis.ResultsAs a new medical gas signal molecule, H2S could regulate autophagy by regulating multiple signal pathways such as Nrf2, NF-κB, MAPK, AMPK, etc., then ameliorated multi-organ dysfunction in sepsis.ConclusionH2S inhibits inflammation, oxidative stress, and apoptosis by regulating autophagy, thus ameliorating multi-organ dysfunction in sepsis, which is expected to become an effective therapeutic target for sepsis.
ObjectiveTo summarize the progress in research on the role of hydrogen sulfide (H2S) in liver diseases. MethodThe relevant literature at home and abroad in recent years was searched and reviewed. ResultsThe H2S played an important role in the occurrence and development of the liver diseases through anti-oxidative stress, anti-inflammation, regulation of autophagy, endoplasmic reticulum stress, angiogenesis, cell death, and other mechanisms. However, the relevant mechanisms are still controversial. Future studies needed to deeply explore the specific role of H2S in the different liver diseases, and how to accurately control its level in vivo and achieve targeted drug administration. ConclusionsThe concentration of H2S in vivo can be regulated by supplementing exogenous H2S, adjusting intestinal microbiota or inhibiting key enzymes of H2S synthesis, which provides a new strategy for the treatment of liver diseases. However, the relevant mechanisms are still controversial, and future research needs to delve into the specific role of H2S in different liver diseases, as well as how to precisely control its levels in vivo and achieve targeted drug delivery.