With the development of medical diagnosis and treatment technology, ultrasound examination has been widely used in clinical practice, but it also faces certain safety hazards. If the ultrasound probe is not effectively disinfected after use, it may be contaminated by pathogenic bacteria transmitted from blood, mucous membranes, genital or rectal secretions, thus becoming a carrier for the transmission of pathogenic bacteria among patients. In addition, the frequent use of ultrasound probe and coupling agent is also an important factor affecting the occurrence of hospital infections. Multiple studies at home and abroad have shown that incomplete cleaning and disinfection of medical ultrasound probe can lead to hospital infection incidents, thereby affecting patient safety and medical quality. Exploring effective disinfection methods and disinfection effects of ultrasound probe is of great significance for hospital infection prevention and control. Therefore, this article provides a review of research related to disinfection of medical ultrasound probe.