Clinical application of MRS combined with long-term VEEG on the surgical treatment of temporal lobe epilepsy_Journal of Epilepsy

Authors：

 WANGHuanming , HUFei , CHENJun , XIONGYubo , CHENYang

Department of Neurosurgery, Wuhan Brain Hospital & Changhang General Hospital, Wuhan, 430010, China;

Corresponding author：

WANGHuanming, Email: 1808381741@qq.com

Keywords：

Temporal lobe epilepsy; MRS; VEEG

DOI：

10.7507/2096-0247.20150034

Video：

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Objective To explore the application value of MRS combined with VEEG on the surgical treatment of temporal lobe epilepsy. Methods There were 31 males and 20 females, age between 4 and 62 years.Their illness duration ranged from 4 to 10 years.The clinical manifestations showed complex partial seizure in 10 cases, secondary generalized seizure in 12 and generalized tonic-clonic seizure in 29. Based on their results of clinical manifestations, MRS and VEEG results, all the patients underwent anterior temporal lobectomy(including the most parts of the hippocampus and amydala). Results The follow-up of 1~3 years after the operation showed seizure free in 36 cases(Engle Ⅰ), and significant improvement in 11(Engle Ⅱ), no improvement in 4 cases(Engle Ⅳ). The overall effective rate was 92.16%. Conclusions MRS combined with VEEG has significant localization value for temporal lobe epilepsy. The prognosis of postoperative result is quiet good to the patient of typical temporal lobe epilepsy after anterior temporal lobectomy.

Citation： WANGHuanming, HUFei, CHENJun, XIONGYubo, CHENYang. Clinical application of MRS combined with long-term VEEG on the surgical treatment of temporal lobe epilepsy. Journal of Epilepsy, 2015, 1(3): 212-216. doi: 10.7507/2096-0247.20150034 Copy

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2.	Kuzniecky R, dela Sayette V, Etheir R, et al. Magnetic resonance imaging in temporal lobe epilepsy:pathologic correlation.Ann Neurol, 1987, 22(8):341-347.
3.	罗超, 陈元媛, 赵林, 等. 1H-MRS磁共振波谱分析对海马硬化诊断的评价.临床军医杂志, 2011, 39(1):117-119.
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5.	Ende GR, Laxer KD, Konwlton RC, et al. Temporal lobe epilepsy:bilateral hippocampal metabolite changes revealed at proton MR spectroscopic imaging.Radiology, 1997, 202(45):809-817.
6.	Vernnathen P, Ende G, Laxer KD, et al. Temporal lobectomy for epilepsy:recovery of the contralateral hippocampus measured by 1H-MRS. Neurology, 2002, 59(10):633-636.
7.	高翔, 江澄川, 洪震, 等.海马硬化与颞叶癫痫的关系.上海医科大学学报, 2000, 27(2):115-116.
8.	Garcia PA, Laxer KD, Bartaro NM, et al. Prognostic value of qualitative magnetic resonance imaging hippocampal abnormalities in patients underlying temporal lobectomy for medically refractory seizure. Epilepsia, 1994, 35(4):520-524.
9.	Kilpatrick C, Cook M, Kaye A, et al. Non-invasive investigations successfully select patients for temporal lobe surgery. J Neurol Neurosurg Psychiatry, 1997, 63(2):327-333.
10.	Jack CR, Cascino GD, Sharbrough FW, et al. Magnetic resonance image-based hippocampal volumetry:correlation with outcome after temporal lobectomy. Ann Neurol, 1992, 31(1):138-146.
11.	周健, 鲍民, 翟锋, 等. MRI阴性的颞叶癫痫的外科治疗.中华神经外科杂志, 2011, 27(12):1241-1243.
12.	许尚臣, 邢毅, 栾立明, 等.不同手术入路治疗海马硬化性颞叶内侧癫痫的比较.中华神经外科杂志, 2012, 28(8):806-809.

1. 谭启富, 李龄, 吴承远.癫痫外科学.2版.北京:人民卫生出版社, 2012, 110-111.
2. Kuzniecky R, dela Sayette V, Etheir R, et al. Magnetic resonance imaging in temporal lobe epilepsy:pathologic correlation.Ann Neurol, 1987, 22(8):341-347.
3. 罗超, 陈元媛, 赵林, 等. 1H-MRS磁共振波谱分析对海马硬化诊断的评价.临床军医杂志, 2011, 39(1):117-119.
4. Connelly A, Van Paessehen W, Porter DA, et al. Proton magnetic resonance spectroscopy in MRI-negative temporal lobe epilepsy. Neurology, 1998, 51(16):61-66.
5. Ende GR, Laxer KD, Konwlton RC, et al. Temporal lobe epilepsy:bilateral hippocampal metabolite changes revealed at proton MR spectroscopic imaging.Radiology, 1997, 202(45):809-817.
6. Vernnathen P, Ende G, Laxer KD, et al. Temporal lobectomy for epilepsy:recovery of the contralateral hippocampus measured by 1H-MRS. Neurology, 2002, 59(10):633-636.
7. 高翔, 江澄川, 洪震, 等.海马硬化与颞叶癫痫的关系.上海医科大学学报, 2000, 27(2):115-116.
8. Garcia PA, Laxer KD, Bartaro NM, et al. Prognostic value of qualitative magnetic resonance imaging hippocampal abnormalities in patients underlying temporal lobectomy for medically refractory seizure. Epilepsia, 1994, 35(4):520-524.
9. Kilpatrick C, Cook M, Kaye A, et al. Non-invasive investigations successfully select patients for temporal lobe surgery. J Neurol Neurosurg Psychiatry, 1997, 63(2):327-333.
10. Jack CR, Cascino GD, Sharbrough FW, et al. Magnetic resonance image-based hippocampal volumetry:correlation with outcome after temporal lobectomy. Ann Neurol, 1992, 31(1):138-146.
11. 周健, 鲍民, 翟锋, 等. MRI阴性的颞叶癫痫的外科治疗.中华神经外科杂志, 2011, 27(12):1241-1243.
12. 许尚臣, 邢毅, 栾立明, 等.不同手术入路治疗海马硬化性颞叶内侧癫痫的比较.中华神经外科杂志, 2012, 28(8):806-809.

Journal of Epilepsy

Clinical application of MRS combined with long-term VEEG on the surgical treatment of temporal lobe epilepsy

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