Objective To compare the curative effect of levetiracetam combined with lamotrigine and sodium valproate on postoperative patients with temporal lobe epilepsy.
Methods A total of 186 postoperative patients with temporal lobe epilepsy during August 2012 to August 2014 in our hospital were divided into levetiracetam combined with lamotrigine group (n=98), and sodium valproate group (n=88) based on postoperative different antiepileptic drugs treatment. Antiepileptic treatment were followed up for 12~48 months.Curative effect and adverse reaction were observed. Reservation rates and incidence rates of adverse reaction were calculated in the two groups.
Results In levetiracetam combined with lamotrigine group, EngelⅠratio was 72.4%(71), EngelⅡratio was 17.3%(17), EngelⅢratio was 7.1%(7), and EngelⅣratio was 3.2%(3);in sodium valproate group, EngelⅠratio was 67.0%(59), EngelⅡratio was 21.6%(19), EngelⅢratio was 9.1%(8), and EngelⅣratio was 2.3%(2), and the difference was not statistically significant in the same grade of two groups (P > 0.05).Reservation rate and incidence rate of adverse reaction in levetiracetam combined with lamotrigine group were 90.8%(89) and 15.3%(15) respectively.While those in sodium valproate group were 80.7%(71) and 36.4%(32) respectively.The differences were statistically significant between the two groups (P < 0.05).
Conclusions Levetiracetam combined with lamotrigine treatment on postoperative patients with temporal lobe epilepsy may have better curative effects than sodium valproate treatment, and levetiracetam combined with lamotrigine has its advantage in reservation rate and less adverse reaction.
Citation：
CHENJie, TIANHuan, LEIding. Curative effect of levetiracetam combined with lamotrigine and sodium valproate postoperative patients with temporal lobe epilepsy. Journal of Epilepsy, 2015, 1(3): 209-211. doi: 10.7507/2096-0247.20150033
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Copyright © the editorial department of Journal of Epilepsy of West China Medical Publisher. All rights reserved
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丁庆明, 任连坤.抗癫痫新药左乙拉西坦的临床应用和安全性.药物不良反应杂志, 2007, 9(4):295.
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郑乃智, 张慧娟, 宋旭霞.拉莫三嗪添加治疗难治性癫痫的临床观察.临床神经电生理学杂志, 2006, 15(4):222-228.
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罗榕, 刘凌, 司洋.拉莫三嗪治疗癫痫的疗效及安全性分析.现代预防医学杂志, 2011, 38(21):4550-4554.
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渝东山, 李广录, 汪春运.丙戊酸钠的不良反应研究新进展.国际神经病学神经外科学杂志, 2005, 32(4):319-321.
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- 1. 刘宗惠.癫痫外科治疗进展.中华神经外科杂志, 2000, 16(增刊):67-70.
- 2. Fiest KM, Sajobi TT, Wiebe S. Epilepsy surgery and meaningful improvements in quality of life:results from a randomized controlled trial. Epilepsia, 2014, 55 (6):886-892.
- 3. Berkovic SF. Surgical treatment of temporal lobe epilepsy. J Neurol Neurosurg Psyhciatry, 2002, 73(5):470.
- 4. 郑康, 吴刚, 王硕.神经外科术后早期癫痫的治疗及病因研究.中华神经医学杂志, 2006, 5(1):73-75.
- 5. 栾国明.颞叶癫痫的外科治疗.中国全科医学, 2006, 9(17):1408-1409.
- 6. Carunchio I, Pieri M, Ciotti MT, et al. Modulation of AMPA receptors in cultured cortical neurons induced by antiepileptic drug levetiracetam. Epilepsia, 2007, 48(4):654-662.
- 7. Striano P, Goppola A, Pezzella M, et al. An open-label trial of levetiracetam in severe myoclonic epilepsy of infancy. Neurology, 2007, 69(3):250-254.
- 8. 丁庆明, 任连坤.抗癫痫新药左乙拉西坦的临床应用和安全性.药物不良反应杂志, 2007, 9(4):295.
- 9. 郑乃智, 张慧娟, 宋旭霞.拉莫三嗪添加治疗难治性癫痫的临床观察.临床神经电生理学杂志, 2006, 15(4):222-228.
- 10. 罗榕, 刘凌, 司洋.拉莫三嗪治疗癫痫的疗效及安全性分析.现代预防医学杂志, 2011, 38(21):4550-4554.
- 11. 渝东山, 李广录, 汪春运.丙戊酸钠的不良反应研究新进展.国际神经病学神经外科学杂志, 2005, 32(4):319-321.
