Research progress of mitochondrial quality control in leukemia_West China Medical Journal

Authors：

WEI Jing ^1,2 , CHEN Xingbiao ^1,2 ,  LU Ziyuan ¹

1. Department of Hematology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; the Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510150, P. R. China;
2. Department of Clinical Medicine, Guangzhou Medical University, Guangzhou, Guangdong 510150, P. R. China;

Corresponding author：

LU Ziyuan, Email: lzo19880306@126.com

Keywords：

Mitochondrial quality control; leukemia; immunomodulation; immunotherapy

DOI：

10.7507/1002-0179.202408274

Video：

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Mitochondrial quality control includes mechanisms such as mitochondria-derived vesicles, fusion / fission and autophagy. These processes rely on the collaboration of a variety of key proteins in the inner and outer membranes of mitochondria to jointly regulate the morphological structure and functional integrity of mitochondria, repair mitochondrial damage, and maintain the homeostasis of their internal environment. The imbalance of mitochondrial quality control is associated with leukemia. Therefore, by exploring the mechanisms related to mitochondrial quality control of various leukemia cells and their interactions with immune cells and immune microenvironment, this article sought possible targets in the treatment of leukemia, providing new ideas for the immunotherapy of leukemia.

Citation： WEI Jing, CHEN Xingbiao, LU Ziyuan. Research progress of mitochondrial quality control in leukemia. West China Medical Journal, 2024, 39(12): 1970-1977. doi: 10.7507/1002-0179.202408274 Copy

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