Research progress on programmed cell death in immunoglobulin A nephropathy_West China Medical Journal

Authors：

RAN Yingfang ¹ , CHEN Caihe ¹ ,  HUANG Wenhui ²

1. The First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, P. R. China;
2. Department of Nephrology, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P. R. China;

Corresponding author：

HUANG Wenhui, Email: huangwh9966@163.com

Keywords：

Immunoglobulin A nephropathy; apoptosis; autophagy; pyroptosis; ferroptosis; cuproptosis

DOI：

10.7507/1002-0179.202407062

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Immunoglobulin A nephropathy (IgAN) is an immune-mediated chronic inflammatory disease with a complex pathogenesis and diverse clinical manifestations. Currently, there is no specific treatment plan. Programmed cell death is an active and orderly way of cell death controlled by genes in the body, which maintains the homeostasis of the body and the development of organs and tissues by participating in various molecular signaling pathways. In recent years, programmed cell death has played an important regulatory role in the occurrence and development of IgAN, involving complex signaling pathways. Under pathological conditions, it may relieve kidney damage through various pathways such as reducing oxidative stress, inhibiting inflammation, and improving energy metabolism. This article provides a review of the research progress of IgAN in apoptosis, autophagy, pyroptosis, ferroptosis,and cuproptosis in order to provide new therapeutic targets for IgAN.

Citation： RAN Yingfang, CHEN Caihe, HUANG Wenhui. Research progress on programmed cell death in immunoglobulin A nephropathy. West China Medical Journal, 2024, 39(12): 1964-1969. doi: 10.7507/1002-0179.202407062 Copy

1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.	Zhai P, Sung EA, Shiheido-Watanabe Y, et al. Suppression of autophagy induces senescence in the heart. bioRxiv, 2024: 2024.05. 26.595978.
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
39.
40.
41.
42.
43.
44.
45.
46.
47.
48.
49.
50.
51.
52.
53.
54.

1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18. Zhai P, Sung EA, Shiheido-Watanabe Y, et al. Suppression of autophagy induces senescence in the heart. bioRxiv, 2024: 2024.05. 26.595978.
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
39.
40.
41.
42.
43.
44.
45.
46.
47.
48.
49.
50.
51.
52.
53.
54.

Previous Article
Research progress on venous thromboembolism in patients with cerebral hemorrhage
Next Article
Research progress of mitochondrial quality control in leukemia

West China Medical Journal

Research progress on programmed cell death in immunoglobulin A nephropathy

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content