Objective To address the "three-low predicament" in China’s valvular heart disease (VHD) diagnosis and treatment system (low detection rate, low intervention rate, and low follow-up rate), and to propose and implement a whole life cycle management model for VHD considering the increasing burden of degenerative valvular disease in the context of an aging population. Methods Since 2020, West China Hospital of Sichuan University has established a management system encompassing "assessment-decision-intervention-follow-up", including: (1) a risk-stratified, tiered management pathway; (2) six core functions ("promotion, screening, prevention, diagnosis, treatment, and rehabilitation") coordinated by disease-specific managers; (3) an intelligent decision support information platform; and (4) a collaborative network of multidisciplinary teams and regional academic alliances. Results Between 2020 and 2024, a total of 583 874 echocardiographic screenings were completed, identifying 3 401 (7.1%) high-risk patients with aortic valve disease, 18 657 (38.8%) medium-risk patients, and 26 031 (54.1%) low-risk patients. A total of 2 417 patients were enrolled in whole life cycle management. Patient satisfaction scores increased year by year, from 73.89 before 2020 to 93.74 in 2024. The 1-year mortality rate in the transcatheter aortic valve replacement (TAVR) cohort decreased from 8.2% to 5.3% (P<0.01). Conclusion The VHD whole life cycle management model, through optimized processes and integrated resources, has achieved significant results in standardizing diagnosis and follow-up procedures, improving patient satisfaction and quality of life, and reducing mortality. It provides a scalable practical model for VHD management in China.