ObjectiveTo investigate the safety of day surgery service model for one-stage prosthetic reconstruction after endoscopic radical mastectomy for breast cancer. MethodsThe breast cancer patients who underwent prosthesis reconstruction after endoscopic radical mastectomy at The First Affiliated Hospital of Air Force Military Medical University from January 2021 to December 2023 were retrospectively collected. The patients were assigned into an ambulatory group (ambulatory surgical service model) and an inpatient unit group (inpatient unit surgical service model) according to their surgical service modalities. The baseline data, surgery-related data, oncological safety-related indexes, and postoperative quality of life indicators by Breast-Q 2.0 score of the two groups were compared. ResultsThere were 239 patients were included, including 146 in the ambulatory group and 93 in the inpatient unit group. Except for the age and menopausal status of the patients of two groups (P<0.05), there were no statistically significant differences in the other baselines of the patients between the two groups (P>0.05). In the surgery-related data, except for the total hospitalization time and postoperative drainage in the ambulatory group, which were significantly less than those in the inpatient unit group (P<0.05), the differences between the two groups in terms of operation time, intraoperative bleeding, prosthesis size, postoperative dietary recovery time, postoperative pain score, and axillary lymph node dissection rate were not statistically significant (P>0.05). No significant differences were seen in the incidences of nipple-areola complex ischemia, flap ischemia, infection, implant loss, and capsular contracture (P>0.05). In the Breast-Q 2.0 score, the information satisfaction of the patients in the ambulatory group was significantly higher than that of in the inpatient unit group (P＜0.05), and there were no statistical significances in the breast satisfaction, social satisfaction, and physician satisfaction (P>0.05). The average follow-up time in the ambulatory group and inpatient unit group was (13.31±7.29) months and (13.41±9.02) months, respectively. All patients survived, among them, one patient (0.68%) in the ambulatory group and two patients (2.15%) in the inpatient unit group experienced local recurrence, and there was no significant difference in the rate of local recurrence between the two groups (P>0.05). ConclusionFrom the results of this study, day surgery for one-stage prosthetic reconstruction after endoscopic radical mastectomy for breast cancer is safe and can also improve the patient’s experience of care.