Soluble interleukin-2 recepter(sIL-2R）levels, NK activity and T lymphocyte subpopulation in peripheral blood were determined in 34 cases of primary liver cancer (PLC). The results showed that the mean level of sIL-2R and CD8 in the patients with primary liver cancer were higher than that in health subjects (P lt;0.01or P lt;0.05), NK activity and T lymphocyte subpopulation (CD3,CD4,CD4/CD8) in the patients with primary liver cancer were much lower than that in health subjects (P lt;0.01), sIL-2R levels in stage II, III patients with primary liver cancer were significantly higher than that in stage I (P lt;0.01). The 6-month mortality rate in 3 groups of patients with sIL-2R level ≥1000u/ml, 500-1000u/ml, and lt;500u/ml were 80.0%, 29.4%and 0 respectively. sIL-2R levels were also decreased (P lt;0.05) in patient with primary liver cancer 4 weeks after immune therapy, but the cell-mediated immunity was increased. It suggests that sIL-2R level determination in peripheral blood is a new biological marker for the assessment of the stage, the response to medical intervention, the prognosis and cell-mediated immunity in primary liver cancer.
Citation：
Yang Dinghua,Li Shaosen,Peng Minghao,et al.. CHANGE OF SOLUBLE INTERLEUKIN-2 RECEPTOR AND ITS SIGNIFICANCE IN PRIMARY LIVER CANCER. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1996, 3(2): 65-67. doi:
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- 1. Rubin LA, Kurman CC, Fritz ME, et al. Soluble interleukin-2 receptors are released from activated human lymphoid cells in vitro. J Immunol, 1985; 135: 3172.
- 2. Nelson DL, Warner C. The human interleukin-2 receptor normal and abnormal expression in T-cells and in leukemias induced by the human T-lymphotropic retroviruses. Ann Intern Med, 1986; 105: 560.
- 3. 汤钊猷主编. 现代肿瘤学. 第一版. 上海：上海医科大学出版社，1993：553~585.
- 4. 陈绍先，周华鸣，郭彩云. 白血病病人NK功能的改变及几种介质对正常人NK功能的影响. 中国实验临床免疫学杂志，1989；1（1~2）：3.
- 5. Manoussakis MN, Papadopoulos GK, Drosos AA, et al. Soluble interleukin-2 receptor molecules in the serum of patients with autoimmne disease. Clin Immunol Immunopathol, 1989; 50: 321.
- 6. 富宁，朱迅，杨贵贞.可溶性白细胞介素-2受体及其生物学意义.国外医学免疫学分册，1989；12：225.
- 7. Semenzato G, Agostini OC, Zambello R, et al. High serum levels of soluble interleukin 2 receptor in patients with B chronic lymphocytic leukemia. Blood, 1987; 70: 396.
