The aim of this study was to investigate the role of tumor necrosis factor (TNF), interleukin-6(IL-6), C-reactive protein (CRP) in pancreatitis and its systemic complications. Thirty six patients with acute pancreatitis were studied, 12 with mild disease, and 24 severe disease, of whom 9 developed systemic complications. TNF, IL-6, CRP in these patients with pancreatitis was assessed during the first, 4th, 8th days of admission. The serum concentration of TNF, IL-6, CRP were significantly increased, and significantly higher in complicated group than in mild group and severe group. These findings suggest that proinflammatory cytokines play a central role in the pathophysiology of the disease, the host systemic response to pancreatic inflammation and the level of the response did relate to the development of organ dysfunction.
Citation：
Liu Mulin,Cao Weixin,Tang Yaoqing,et al.. SERUM TUMOR NECROSIS FACTOR, INTERLEUKIN-6, C-REACTIVE PROTEIN IN ASSESSMENT OF SEVERITY OF ACUTE PANCREATITIS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(6): 352-353下转384. doi:
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- 1. Beaux AC, Goldie AS, Ross JA, et al. Serum concentrations of inflammatory mediators related to organ failure in patients with acute pancreatitis. British J Surg, 1996; 83(4)∶349.
- 2. Heath DI, Cruickshank A, Gudgeon M, et al. Role of interleukin 6 in mediating the acute phase protein response and potential as and early means of severity assessment in acute pancreatitis. Gut, 1993; 34∶41.
- 3. Deitch EA. Multiple organ failure. Ann Surg, 1992; 216(2)∶117.
- 4. Mckay CJ, Gallagher G, Brooks B, et al. Increased monocyte cytokine production in association with systemic complication in acute pancreatitis. Br J Surg, 1996; 83(7)∶919.
- 5. Pezzilli R, Billi P, Miniero R, et al. Serum interleukin6, interleukin8, and β2microglobulin in early assessment of severity of acute pancreatitis comparison with serum creactive protein. Dig Dis Sci, 1995; 40(11)∶2341.
- 6. Rinderknecht H. Genetic determinants of mortality in acute necrotizing pancreatitis. Int J Pancreatol, 1994; 16(1)∶11.
