Evidence-based construction of evaluation items for selecting priority clinical questions of traditional Chinese medicine guidelines_Chinese Journal of Evidence-Based Medicine

Authors：

HU Ziteng ¹ , CHEN Yaxin ^1,2 , ZHANG Haili ¹ , LI Huizhen ¹ , ZHANG Yujing ¹ , LIU Yuqi ¹ , ZHAO Chen ¹ , CAO Wenjie ¹ , WANG Weili ¹ , ZONG Xingyu ¹ , YANG Yijiu ¹ , ZHANG Fuqiang ¹ , WANG Yanping ¹ ,  LIANG Ning ¹ ,  SHI Nannan ¹

1. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, P. R. China;
2. Amsterdam University Medical Center, Amsterdam 1105AZ, Netherlands;

Corresponding author：

LIANG Ning, Email: 13811839164@vip.126.com; SHI Nannan, Email: 13811839164@vip.126.com

Keywords：

Traditional Chinese medicine; Guideline; Clinical questions; Priority setting

DOI：

10.7507/1672-2531.202404091

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the items affecting the prioritization of clinical questions and to construct an evaluation scale for prioritizing clinical question of traditional Chinese medicine (TCM) guidelines. Methods Literature analysis and cognitive interview were used to construct the pool of items for evaluating the prioritization of clinical questions of TCM guidelines, and Delphi methods was used to identify the items to form the evaluation scale. Results A total of 47 articles were included in the literature, and the two rounds of Delphi questionnaires had a recovery rate of 72% and 100%, respectively. The mean value of the importance of the items in the first round ranged from 3.78 to 4.78, with a coefficient of variation ranging from 0.09 to 0.30, and the mean value in the second round ranged from 4.06 to 4.72, with a coefficient of variation ranging from 0.09 to 0.29. The evaluation scale for the prioritization of clinical questions of TCM guidelines (first edition) was constructed, which contains 13 entries in 4 dimensions. Conclusion This study explored the items affecting the prioritization of clinical questions in TCM guidelines and developed a prioritization evaluation scale, which improved the lack of objectivity and interpretability of the current prioritization of clinical questions in TCM guidelines to a certain extent, and strengthened the transparency of the process of selecting clinical issues in TCM guidelines.

1.	Institute of Medicine (US) Committee on Standards for Developing Trustworthy Clinical Practice Guidelines. Clinical practice guidelines we can trust. Washington (DC): National Academies Press (US), 2011.
2.	World Health Organization. WHO handbook for guideline development (2nd ed). Geneva: World Health Organization, 2014.
3.	National Institute for Health and Care Excellence. Developing NICE guidelines: the manual. London: National Institute for Health and Care Excellence (NICE), 2015.
4.	SIGN. A guideline developer’s handbook. Edinburgh: SIGN, 2015.
5.	Department of Health (DOH), National Clinical Effectiveness Committee (NCEC). How to develop a national clinical guideline: a manual for guideline developers. Dublin: Department of Health (DoH), 2019.
6.	Department of Health-Philippines, Philippine Health Insurance Corporation. Manual for clinical practice guideline development. Philippine: Department of Health Philippines, 2018.
7.	倪小佳, 陈耀龙, 蔡业峰. 中西医结合脑卒中循证实践指南(2019). 中国循证医学杂志, 2020, 20(8): 901-912.
8.	田丹, 钱序, 韩鹏, 等. 公共卫生基本项目优先重点评价指标的建立. 中国初级卫生保健, 2010, 24(11): 65-67.
9.	方振威, 石秀锦, 周鹏翔, 等. 《P2Y_(12)受体拮抗剂用于急性冠状动脉综合征或经皮冠状动脉介入治疗患者精准治疗快速建议指南》临床问题与结局指标的确定. 临床药物治疗杂志, 2021, 19(7): 37-42.
10.	Wiercioch W, Nieuwlaat R, Zhang Y, et al. New methods facilitated the process of prioritizing questions and health outcomes in guideline development. J Clin Epidemiol, 2022, 143: 91-104.
11.	Sanabria AJ, Pardo-Hernandez H, Ballesteros M, et al. The UpPriority tool was developed to guide the prioritization of clinical guideline questions for updating. J Clin Epidemiol, 2020, 126: 80-92.
12.	陈耀龙, 刘萧, 王燕平, 等. 西医指南与中医药指南: 在相互学习中共同提高. 协和医学杂志, 2020, 11(5): 615-620.
13.	Willis G. Cognitive interviewing: a tool for improving questionnaire design. Thousand Oaks, Calif. : Sage Publications, 2004.
14.	KDIGO. KDIGO methods manual for guideline development. Washington (DC): KDIGO, 2022.
15.	Gupta S, Bhattacharyya OK, Brouwers MC, et al. Canadian thoracic society: presenting a new process for clinical practice guideline production. Can Respir J, 2009, 16(6): e62-e68.
16.	陈耀龙, 杨克虎, 王小钦, 等. 中国制订/修订临床诊疗指南的指导原则(2022版). 中华医学杂志, 2022, 102(10): 697-703.
17.	The Saudi Center for Evidence Based Health Care. Saudi Arabian handbook for healthcare guideline development, Version 1.0. Saudi Arabia: The Saudi Center for Evidence Based Health Care, 2014.
18.	Agbassi C, Messersmith H, McNair S, et al. Priority-based initiative for updating existing evidence-based clinical practice guidelines: the results of two iterations. J Clin Epidemiol, 2014, 67(12): 1335-1342.
19.	Amos Q, Chan W, Tom G. Maximising efficiency in updating guidelines through prioritisation of clinical questions. BMJ Qual Saf, 2013, 22(Suppl 1): A19.
20.	Chang S. When to update, when to Archive? The AHRQ EPC program. Quebec: Updating Cochrane Reviews Workshop, 2014.
21.	Jamshidi A, Lamontagne M, Ait-Kadi D, et al. Developing a comprehensive priority-based framework for updating clinical practice guidelines (CPGs): a systematic review and international survey. Quebec: Huitieme Colloque Etudiant du CIRRIS, 2016.
22.	Jordan-Cole V, Farquhar C, Brown J, et al. Centralised updating officer pilot project: a project of the cochrane collaboration final report: August 2008. 2008.
23.	Salzwedel D, Wright J. Citation rates of systematic reviews of inter ventions for hypertension and blood pressure. In: Bero L, Montgomery P, Robinson K, et al, editors. Bringing evidence-based decision-making to new heights. Abstracts of the 2010 Joint Colloquium of the Cochrane and Campbell Collabo rations. Keystone: John Wiley & Sons, 2010.
24.	Soll RF. Updating reviews: the experience of the Cochrane Neonatal Review Group. Paediatr Perinat Epidemiol, 2008, 22(Suppl 1): 29-32.
25.	Takwoingi Y, Hopewell S, Tovey D, et al. A multicomponent decision tool for prioritising the updating of systematic reviews. BMJ, 2013, 347: f7191.
26.	Theobald S, Blanc-Vincent Mp, Farsi F, et al. The identification of questions in the updating process of clinical practice guidelines for oncology. Edinburgh: 15th Annual Meeting of the International Society of Technology Assessment in Health Care, 1999.
27.	Venhorst K, Ploegmakers M, Holtus A, et al. What isneeded to realize a dynamic process of guideline updating. Melbourne: 11th G-I-N Conference, 2014.
28.	Welsh E, Stovold E, Karner C, et al. Cochrane airways group reviews were prioritized for updating using a pragmatic approach. J Clin Epidemiol, 2015, 68(3): 341-346.
29.	Battista RN, Hodge MJ. Setting priorities and selecting topics for clinical practice guidelines. CMAJ, 1995, 153(9): 1233-1237.
30.	Schünemann HJ, Wiercioch W, Etxeandia I, et al. Guidelines 2. 0: systematic development of a comprehensive checklist for a successful guideline enterprise. CMAJ, 2014, 186(3): E123-E142.
31.	Institute of Medicine (US) Committee on Methods for Setting Priorities for Guidelines Development. Setting priorities for clinical practice guidelines. Washington (DC): National Academies Press (US), 1995.
32.	McClarey M, Duff L. Identifying priorities for national clinical guidelines. Nurs Stand, 1999, 13(41): 37-41.
33.	Oxman AD, Schünemann HJ, Fretheim A. Improving the use of research evidence in guideline development: 2. Priority setting. Health Res Policy Syst, 2006, 4: 14.
34.	Ketola E, Toropainen E, Kaila M, et al. Prioritizing guideline topics: development and evaluation of a practical tool. J Eval Clin Pract, 2007, 13(4): 627-631.
35.	Reveiz L, Tellez DR, Castillo JS, et al. Prioritization strategies in clinical practice guidelines development: a pilot study. Health Res Policy Syst, 2010, 8: 7.
36.	Atkins D, Perez-Padilla R, Macnee W, et al. Priority setting in guideline development: article 2 in Integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report. Proc Am Thorac Soc, 2012, 9(5): 225-228.
37.	Reddy BP, Kelly MP, Thokala P, et al. Prioritising public health guidance topics in the National Institute for Health and Care Excellence using the Analytic Hierarchy Process. Public Health, 2014, 128(10): 896-903.
38.	Mounesan L, Sayarifard A, Haghjou L, et al. A manual for prioritizing the topics of clinical practice guidelines for family physicians. Int J Prev Med, 2016, 7: 64.
39.	Becker M, Jaschinski T, Eikermann M, et al. A systematic decision-making process on the need for updating clinical practice guidelines proved to be feasible in a pilot study. J Clin Epidemiol, 2018, 96: 101-109.
40.	Borgonjen RJ, van Everdingen JJ, van de Kerkhof PC, et al. Prioritizing dermatoses: rationally selecting guideline topics. J Eur Acad Dermatol Venereol, 2015, 29(8): 1636-1640.
41.	Jo HS, Kim DI, Oh MK. National priority setting of clinical practice guidelines development for chronic disease management. J Korean Med Sci, 2015, 30(12): 1733-1742.
42.	Loeffen EA, Mulder RL, Kremer LC, et al. Development of clinical practice guidelines for supportive care in childhood cancer--prioritization of topics using a Delphi approach. Support Care Cancer, 2015, 23(7): 1987-1995.
43.	van der Veer SN, van Biesen W, Bernaert P, et al. Priority topics for European multidisciplinary guidelines on the management of chronic kidney disease in older adults. Int Urol Nephrol, 2016, 48(6): 859-869.
44.	Aleksovska K, Bassetti CLA, Berger T, et al. Prioritization process for European Academy of Neurology clinical practice guidelines. Eur J Neurol, 2023, 30(2): 305-320.
45.	Shekelle PG, Motala A, Johnsen B. Assessment of a method to detect signals for updating systematic reviews. Rockville (MD): Agency for Healthcare Research and Quality (US), 2014.
46.	康晓凤, 吕蓉, 张方圆, 等. 《成人急性心力衰竭护理实践指南》优先主题的确定. 中国护理管理, 2016, 16(9): 1191-1195.
47.	老膺荣. 对中医及中西医结合临床治疗指南制订中几个重要环节的思考. 中国中西医结合杂志, 2010, 30(3): 237-240.
48.	郝云霞, 李庆印, 秦培培, 等. 急诊经皮冠状动脉介入治疗护理实践指南优先主题与结局指标的确定. 中国护理管理, 2019, 19(7): 996-999.
49.	靳英辉, 韩斐, 王强, 等. 临床实践指南制订方法—指南范围、主题及问题的确定. 中国循证心血管医学杂志, 2018, 10(3): 257-261.
50.	杨颖, 毕颖斐, 王贤良, 等. 《中成药治疗冠心病临床应用指南》临床问题的构建. 中医杂志, 2021, 62(18): 1582-1587.
51.	李小科, 叶永安, 杜宏波. 基于2015年版慢性乙型肝炎防治指南谈中医药治疗的机遇与挑战. 世界中医药, 2016, 11(2): 364-367.
52.	陈浩, 史大卓. 近年临床试验及指南对中西医结合治疗冠心病的启示. 中西医结合心脑血管病杂志, 2009, 7(4): 379-381.
53.	卞立群, 陈婷, 程荟蓉, 等. 消化系统中成药应用指南的编制问题解析. 中国中西医结合杂志, 2020, 40(5): 620-623.
54.	陈薇, 刘建平. 中西医结合临床实践指南制订原则和流程. 中国中西医结合杂志, 2022, 42(12): 1413-1417.
55.	杨思红, 陈可冀, 刘建平, 等. 中医药临床实践指南从证据到推荐意见形成要目和解读. 中国中西医结合杂志, 2021, 41(4): 494-498.
56.	徐浩, 董红军, 陈旭青, 等. 《中医治未病实践指南·鼻鼽》临床一致性评价研究. 中国中医药信息杂志, 2018, 25(3): 16-18.
57.	高一城, 刘芷含, 夏如玉, 等. 中医药临床实践指南临床问题构建中干预措施的优先性选择—基于专家证据的方法学建议. 中国循证医学杂志, 2023, 23(4): 433-438.
58.	Talsma E, de Jonge R, Cassel F, et al. Implementation of nationwide evidence- and consensus-based guidelines to harmonize neonatal care in the Netherlands. Indian Pediatr, 2022, 59(5): 371-376.
59.	李慧, 陈耀龙, 韦当, 等. 中医(中西医结合)临床实践指南制修订方法—临床问题的构建. 中华中医药杂志, 2016, 31(6): 2202-2205.

1. Institute of Medicine (US) Committee on Standards for Developing Trustworthy Clinical Practice Guidelines. Clinical practice guidelines we can trust. Washington (DC): National Academies Press (US), 2011.
2. World Health Organization. WHO handbook for guideline development (2nd ed). Geneva: World Health Organization, 2014.
3. National Institute for Health and Care Excellence. Developing NICE guidelines: the manual. London: National Institute for Health and Care Excellence (NICE), 2015.
4. SIGN. A guideline developer’s handbook. Edinburgh: SIGN, 2015.
5. Department of Health (DOH), National Clinical Effectiveness Committee (NCEC). How to develop a national clinical guideline: a manual for guideline developers. Dublin: Department of Health (DoH), 2019.
6. Department of Health-Philippines, Philippine Health Insurance Corporation. Manual for clinical practice guideline development. Philippine: Department of Health Philippines, 2018.
7. 倪小佳, 陈耀龙, 蔡业峰. 中西医结合脑卒中循证实践指南(2019). 中国循证医学杂志, 2020, 20(8): 901-912.
8. 田丹, 钱序, 韩鹏, 等. 公共卫生基本项目优先重点评价指标的建立. 中国初级卫生保健, 2010, 24(11): 65-67.
9. 方振威, 石秀锦, 周鹏翔, 等. 《P2Y_(12)受体拮抗剂用于急性冠状动脉综合征或经皮冠状动脉介入治疗患者精准治疗快速建议指南》临床问题与结局指标的确定. 临床药物治疗杂志, 2021, 19(7): 37-42.
10. Wiercioch W, Nieuwlaat R, Zhang Y, et al. New methods facilitated the process of prioritizing questions and health outcomes in guideline development. J Clin Epidemiol, 2022, 143: 91-104.
11. Sanabria AJ, Pardo-Hernandez H, Ballesteros M, et al. The UpPriority tool was developed to guide the prioritization of clinical guideline questions for updating. J Clin Epidemiol, 2020, 126: 80-92.
12. 陈耀龙, 刘萧, 王燕平, 等. 西医指南与中医药指南: 在相互学习中共同提高. 协和医学杂志, 2020, 11(5): 615-620.
13. Willis G. Cognitive interviewing: a tool for improving questionnaire design. Thousand Oaks, Calif. : Sage Publications, 2004.
14. KDIGO. KDIGO methods manual for guideline development. Washington (DC): KDIGO, 2022.
15. Gupta S, Bhattacharyya OK, Brouwers MC, et al. Canadian thoracic society: presenting a new process for clinical practice guideline production. Can Respir J, 2009, 16(6): e62-e68.
16. 陈耀龙, 杨克虎, 王小钦, 等. 中国制订/修订临床诊疗指南的指导原则(2022版). 中华医学杂志, 2022, 102(10): 697-703.
17. The Saudi Center for Evidence Based Health Care. Saudi Arabian handbook for healthcare guideline development, Version 1.0. Saudi Arabia: The Saudi Center for Evidence Based Health Care, 2014.
18. Agbassi C, Messersmith H, McNair S, et al. Priority-based initiative for updating existing evidence-based clinical practice guidelines: the results of two iterations. J Clin Epidemiol, 2014, 67(12): 1335-1342.
19. Amos Q, Chan W, Tom G. Maximising efficiency in updating guidelines through prioritisation of clinical questions. BMJ Qual Saf, 2013, 22(Suppl 1): A19.
20. Chang S. When to update, when to Archive? The AHRQ EPC program. Quebec: Updating Cochrane Reviews Workshop, 2014.
21. Jamshidi A, Lamontagne M, Ait-Kadi D, et al. Developing a comprehensive priority-based framework for updating clinical practice guidelines (CPGs): a systematic review and international survey. Quebec: Huitieme Colloque Etudiant du CIRRIS, 2016.
22. Jordan-Cole V, Farquhar C, Brown J, et al. Centralised updating officer pilot project: a project of the cochrane collaboration final report: August 2008. 2008.
23. Salzwedel D, Wright J. Citation rates of systematic reviews of inter ventions for hypertension and blood pressure. In: Bero L, Montgomery P, Robinson K, et al, editors. Bringing evidence-based decision-making to new heights. Abstracts of the 2010 Joint Colloquium of the Cochrane and Campbell Collabo rations. Keystone: John Wiley & Sons, 2010.
24. Soll RF. Updating reviews: the experience of the Cochrane Neonatal Review Group. Paediatr Perinat Epidemiol, 2008, 22(Suppl 1): 29-32.
25. Takwoingi Y, Hopewell S, Tovey D, et al. A multicomponent decision tool for prioritising the updating of systematic reviews. BMJ, 2013, 347: f7191.
26. Theobald S, Blanc-Vincent Mp, Farsi F, et al. The identification of questions in the updating process of clinical practice guidelines for oncology. Edinburgh: 15th Annual Meeting of the International Society of Technology Assessment in Health Care, 1999.
27. Venhorst K, Ploegmakers M, Holtus A, et al. What isneeded to realize a dynamic process of guideline updating. Melbourne: 11th G-I-N Conference, 2014.
28. Welsh E, Stovold E, Karner C, et al. Cochrane airways group reviews were prioritized for updating using a pragmatic approach. J Clin Epidemiol, 2015, 68(3): 341-346.
29. Battista RN, Hodge MJ. Setting priorities and selecting topics for clinical practice guidelines. CMAJ, 1995, 153(9): 1233-1237.
30. Schünemann HJ, Wiercioch W, Etxeandia I, et al. Guidelines 2. 0: systematic development of a comprehensive checklist for a successful guideline enterprise. CMAJ, 2014, 186(3): E123-E142.
31. Institute of Medicine (US) Committee on Methods for Setting Priorities for Guidelines Development. Setting priorities for clinical practice guidelines. Washington (DC): National Academies Press (US), 1995.
32. McClarey M, Duff L. Identifying priorities for national clinical guidelines. Nurs Stand, 1999, 13(41): 37-41.
33. Oxman AD, Schünemann HJ, Fretheim A. Improving the use of research evidence in guideline development: 2. Priority setting. Health Res Policy Syst, 2006, 4: 14.
34. Ketola E, Toropainen E, Kaila M, et al. Prioritizing guideline topics: development and evaluation of a practical tool. J Eval Clin Pract, 2007, 13(4): 627-631.
35. Reveiz L, Tellez DR, Castillo JS, et al. Prioritization strategies in clinical practice guidelines development: a pilot study. Health Res Policy Syst, 2010, 8: 7.
36. Atkins D, Perez-Padilla R, Macnee W, et al. Priority setting in guideline development: article 2 in Integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report. Proc Am Thorac Soc, 2012, 9(5): 225-228.
37. Reddy BP, Kelly MP, Thokala P, et al. Prioritising public health guidance topics in the National Institute for Health and Care Excellence using the Analytic Hierarchy Process. Public Health, 2014, 128(10): 896-903.
38. Mounesan L, Sayarifard A, Haghjou L, et al. A manual for prioritizing the topics of clinical practice guidelines for family physicians. Int J Prev Med, 2016, 7: 64.
39. Becker M, Jaschinski T, Eikermann M, et al. A systematic decision-making process on the need for updating clinical practice guidelines proved to be feasible in a pilot study. J Clin Epidemiol, 2018, 96: 101-109.
40. Borgonjen RJ, van Everdingen JJ, van de Kerkhof PC, et al. Prioritizing dermatoses: rationally selecting guideline topics. J Eur Acad Dermatol Venereol, 2015, 29(8): 1636-1640.
41. Jo HS, Kim DI, Oh MK. National priority setting of clinical practice guidelines development for chronic disease management. J Korean Med Sci, 2015, 30(12): 1733-1742.
42. Loeffen EA, Mulder RL, Kremer LC, et al. Development of clinical practice guidelines for supportive care in childhood cancer--prioritization of topics using a Delphi approach. Support Care Cancer, 2015, 23(7): 1987-1995.
43. van der Veer SN, van Biesen W, Bernaert P, et al. Priority topics for European multidisciplinary guidelines on the management of chronic kidney disease in older adults. Int Urol Nephrol, 2016, 48(6): 859-869.
44. Aleksovska K, Bassetti CLA, Berger T, et al. Prioritization process for European Academy of Neurology clinical practice guidelines. Eur J Neurol, 2023, 30(2): 305-320.
45. Shekelle PG, Motala A, Johnsen B. Assessment of a method to detect signals for updating systematic reviews. Rockville (MD): Agency for Healthcare Research and Quality (US), 2014.
46. 康晓凤, 吕蓉, 张方圆, 等. 《成人急性心力衰竭护理实践指南》优先主题的确定. 中国护理管理, 2016, 16(9): 1191-1195.
47. 老膺荣. 对中医及中西医结合临床治疗指南制订中几个重要环节的思考. 中国中西医结合杂志, 2010, 30(3): 237-240.
48. 郝云霞, 李庆印, 秦培培, 等. 急诊经皮冠状动脉介入治疗护理实践指南优先主题与结局指标的确定. 中国护理管理, 2019, 19(7): 996-999.
49. 靳英辉, 韩斐, 王强, 等. 临床实践指南制订方法—指南范围、主题及问题的确定. 中国循证心血管医学杂志, 2018, 10(3): 257-261.
50. 杨颖, 毕颖斐, 王贤良, 等. 《中成药治疗冠心病临床应用指南》临床问题的构建. 中医杂志, 2021, 62(18): 1582-1587.
51. 李小科, 叶永安, 杜宏波. 基于2015年版慢性乙型肝炎防治指南谈中医药治疗的机遇与挑战. 世界中医药, 2016, 11(2): 364-367.
52. 陈浩, 史大卓. 近年临床试验及指南对中西医结合治疗冠心病的启示. 中西医结合心脑血管病杂志, 2009, 7(4): 379-381.
53. 卞立群, 陈婷, 程荟蓉, 等. 消化系统中成药应用指南的编制问题解析. 中国中西医结合杂志, 2020, 40(5): 620-623.
54. 陈薇, 刘建平. 中西医结合临床实践指南制订原则和流程. 中国中西医结合杂志, 2022, 42(12): 1413-1417.
55. 杨思红, 陈可冀, 刘建平, 等. 中医药临床实践指南从证据到推荐意见形成要目和解读. 中国中西医结合杂志, 2021, 41(4): 494-498.
56. 徐浩, 董红军, 陈旭青, 等. 《中医治未病实践指南·鼻鼽》临床一致性评价研究. 中国中医药信息杂志, 2018, 25(3): 16-18.
57. 高一城, 刘芷含, 夏如玉, 等. 中医药临床实践指南临床问题构建中干预措施的优先性选择—基于专家证据的方法学建议. 中国循证医学杂志, 2023, 23(4): 433-438.
58. Talsma E, de Jonge R, Cassel F, et al. Implementation of nationwide evidence- and consensus-based guidelines to harmonize neonatal care in the Netherlands. Indian Pediatr, 2022, 59(5): 371-376.
59. 李慧, 陈耀龙, 韦当, 等. 中医(中西医结合)临床实践指南制修订方法—临床问题的构建. 中华中医药杂志, 2016, 31(6): 2202-2205.

Chinese Journal of Evidence-Based Medicine

Latest ArticlesEvidence-based construction of evaluation items for selecting priority clinical questions of traditional Chinese medicine guidelines

Abstract Full text Figures/Tables Video References Cited by

Format

Content