Combination treatment of Qingfei Yihuo capsules in brochiectasis exacerbation: a multi-center randomized controlled clinical trial_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

TANG Wei ¹ , ZHOU Jun ¹ , GAO Xiwen ² , ZHANG Yajuan ² , XUE Min ² , JIE Zhijun ³ , HANG Jingqing ⁴ , YU Feng ⁴ , LU Liwen ⁵ , SONG Ruihong ⁵ , DUAN Yuxiang ⁶ , JIN Xiaoyan ⁶ , CHENG Qijian ⁷ , CAI Xiaoting ⁷ , LUO Jianfeng ⁸ ,  QU Jieming ¹

1. Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University Medical College, Shanghai 200025, P. R. China;
2. Department of Respiratory and Critical Care Medicine, Fudan University Affiliated Minhang Hospital, Shanghai 201199, P. R. China;
3. Department of Respiratory and Critical Care Medicine, Shanghai Fifth People's Hospital Affiliated with Fudan University, Shanghai 200240, P. R. China;
4. Department of Respiratory Medicine, Shanghai Putuo District People's Hospital, Shanghai 200060, P. R. China;
5. Department of Respiratory Medicine, Shanghai Fengxian District Central Hospital, Shanghai 201499, P. R. China;
6. Department of Respiratory Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, P. R. China;
7. Department of Respiratory Medicine, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P. R. China;
8. Institute of Biostatistics, School of Public Health, Fudan University, Shanghai 200032, P. R. China;

Corresponding author：

QU Jieming, Email: jmqu0906@163.com

Keywords：

Qingfei Yihuo capsule; Bronchiectasis; Acute exacerbation

DOI：

10.7507/1671-6205.201810005

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Objective To evaluate the combination efficacy with Qingfei Yihuo capsule and routine antibiotics as well as mucopolytic agents in the treatment of bronchiectasis acute exacerbation.Methods This was a prospective, multi-center, randomized controlled clinical study. The efficacy of Qingfei Yihuo capsule combine with routine antibiotics and mucopolytic agents in the treatment of bronchiectasis acute exacerbation was compared according to the symptom control as well as exacerbation duration. Through randomization, patients received Qingfei Yihuo capsule or placebo combine with routine antibiotics and mucopolytic agents treatment for 10 days. Symptom score of cough, sputum, short of breath pre- and post-treatment as well as the symptom score in daily card were compared between the two groups. The spirometry and St. George respiratory questionnaire (SGRQ) before and after treatment were compared.Results This study was conducted from June 2017 to August 2018. One hundred and ninety patients from 7 centers in 6 hospitals with bronchiectasis acute exacerbation were enrolled in the study. There was statistically improvement of symptom score (including the 9^th and 10^th treatment days) according to the daily card recording in Qingfei Yihuo capsule group compared to the placebo group, but no statistically significant difference was found in spirometry results or SGRQ.Conclusion Qingfei Yihuo capsule has assistant effect on improving respiratory symptoms of bronchiectasis exacerbation.

Citation： TANG Wei, ZHOU Jun, GAO Xiwen, ZHANG Yajuan, XUE Min, JIE Zhijun, HANG Jingqing, YU Feng, LU Liwen, SONG Ruihong, DUAN Yuxiang, JIN Xiaoyan, CHENG Qijian, CAI Xiaoting, LUO Jianfeng, QU Jieming. Combination treatment of Qingfei Yihuo capsules in brochiectasis exacerbation: a multi-center randomized controlled clinical trial. Chinese Journal of Respiratory and Critical Care Medicine, 2019, 18(4): 352-356. doi: 10.7507/1671-6205.201810005 Copy

1.	徐金富, 林洁璐, 瞿介明. 中国支气管扩张症诊治现状及面临的挑战. 中华结核和呼吸杂志, 2017, 40(1): 8-10.
2.	成人支气管扩张症诊治专家共识编写组. 成人支气管扩张症诊治专家共识. 中华结核和呼吸杂志, 2012, 35(7): 485-492.
3.	朱寿光, 张红, 黎耀东, 等. 清肺抑火胶囊的质量标准研究. 海峡药学, 2008, 20(4): 22-25.
4.	杨永曼. 发掘古方" 清肺抑火丸”剂型改革的研制与应用. 海南医学, 2001, 12(10): 85-87.
5.	龚雯. 清肺抑火片的应用体会. 中国学校卫生, 2001, 22(2): 182.
6.	杨莹莹, 刘洁, 蒋蓉芳, 等. 清肺抑火中药干预大气 PM2.5 对大鼠肺部炎症损伤的实验研究. 上海预防医学, 2017, 29(11): 850-856.
7.	Martinez-Garcia MA, Soler-Cataluna JJ, Perpina-Tordera M, et al. Factors associated with lung function decline in adult patients with stable non-cystic fibrosis bronchiectasis. Chest, 2007, 132(5): 1565-1572.
8.	Onen ZP, Gulbay BE, Sen E, et al. Analysis of the factors related to mortality in patients with bronchiectasis. Respir Med, 2007, 101(7): 1390-1397.
9.	李詝, 李久荣, 高金明. 北京协和医院 136 例支气管扩张症住院患者临床特征分析. 中国医学科学院学报, 2014, 36(1): 61-67.
10.	Aliberti S, Lonni S, Dore S, et al. Clinical phenotypes in adult patients with bronchiectasis. Eur Respir J, 2016, 47(4): 1113-1122.
11.	唐薪竣, 刘洁, 宋元林. 支气管扩张症临床表型的研究进展. 国际呼吸杂志, 2018, 38(6): 457-460.

1. 徐金富, 林洁璐, 瞿介明. 中国支气管扩张症诊治现状及面临的挑战. 中华结核和呼吸杂志, 2017, 40(1): 8-10.
2. 成人支气管扩张症诊治专家共识编写组. 成人支气管扩张症诊治专家共识. 中华结核和呼吸杂志, 2012, 35(7): 485-492.
3. 朱寿光, 张红, 黎耀东, 等. 清肺抑火胶囊的质量标准研究. 海峡药学, 2008, 20(4): 22-25.
4. 杨永曼. 发掘古方" 清肺抑火丸”剂型改革的研制与应用. 海南医学, 2001, 12(10): 85-87.
5. 龚雯. 清肺抑火片的应用体会. 中国学校卫生, 2001, 22(2): 182.
6. 杨莹莹, 刘洁, 蒋蓉芳, 等. 清肺抑火中药干预大气 PM2.5 对大鼠肺部炎症损伤的实验研究. 上海预防医学, 2017, 29(11): 850-856.
7. Martinez-Garcia MA, Soler-Cataluna JJ, Perpina-Tordera M, et al. Factors associated with lung function decline in adult patients with stable non-cystic fibrosis bronchiectasis. Chest, 2007, 132(5): 1565-1572.
8. Onen ZP, Gulbay BE, Sen E, et al. Analysis of the factors related to mortality in patients with bronchiectasis. Respir Med, 2007, 101(7): 1390-1397.
9. 李詝, 李久荣, 高金明. 北京协和医院 136 例支气管扩张症住院患者临床特征分析. 中国医学科学院学报, 2014, 36(1): 61-67.
10. Aliberti S, Lonni S, Dore S, et al. Clinical phenotypes in adult patients with bronchiectasis. Eur Respir J, 2016, 47(4): 1113-1122.
11. 唐薪竣, 刘洁, 宋元林. 支气管扩张症临床表型的研究进展. 国际呼吸杂志, 2018, 38(6): 457-460.

Chinese Journal of Respiratory and Critical Care Medicine

Combination treatment of Qingfei Yihuo capsules in brochiectasis exacerbation: a multi-center randomized controlled clinical trial

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