Lung Capacity and Diffusing Capacity in Patients with Chronic Obstructive Pulmonary Disease at Different Stages_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

LiLinwei , DuJing , DengYan , ZuPing , HeTailing , YuanYuru ,  LiangBinmiao

Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China;

Corresponding author：

LiangBinmiao, Email: liangbinmiao@163.com

Keywords：

Chronic obstructive pulmonary disease; Lung capacity; Diffusing capacity for carbon monoxide

DOI：

10.7507/1671-6205.2015108

Video：

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Objective To assess the lung capacity and diffusing capacity in patients with chronic obstructive pulmonary disease (COPD) at different stages. Methods Patients who were diagnosed with COPD between January and March 2015 were recruited in the study. The data of clinical characteristics and spirometry test (the forced expiratory volume in the first second, FEV₁) were collected. Total lung capacity (TLC) and residual volume (RV) were determined by body plethysmography and helium dilution method, and single breath diffusing capacity for carbon monoxide (D_LCO) was also measured. Lung capacity and the deviations between two methods, and D_LCO%pred were compared among the COPD patients at different stages. The correlation of spirometry with lung capacity and D_LCO%pred were analyzed. Results A total of 170 patients with COPD were enrolled. With the severity of COPD, TLC%pred, RV%pred, RV/TLC and the deviations of the ones between two methods increased significantly, but D_LCO%pred reduced significantly. FEV₁%pred were negatively correlated with the deviations of lung capacity between two methods, and positively correlated with D_LCO%pred. Conclusions Compared with helium dilution method, the body plethysmography is more accurate for evaluating the lung capacity of COPD. With the severity of airflow limitation, the diffusing capacity of COPD decreases gradually.

Citation： LiLinwei, DuJing, DengYan, ZuPing, HeTailing, YuanYuru, LiangBinmiao. Lung Capacity and Diffusing Capacity in Patients with Chronic Obstructive Pulmonary Disease at Different Stages. Chinese Journal of Respiratory and Critical Care Medicine, 2015, 14(5): 436-438. doi: 10.7507/1671-6205.2015108 Copy

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10.	Coertjens PC, Knorst MM, Dumke A, et al. Can the single-breath helium dilution method predict lung volumes as measured by whole-body plethysmography? J Bras Pneumol, 2013, 39:675-685.
11.	O'Donnell CR, Bankier AA, Stiebellehner L, et al. Comparison of plethysmographic and helium dilution lung volumes:which is best for COPD? Chest, 2010, 137:1108-1115.
12.	Barnes PJ. Cellular and molecular mechanisms of chronic obstructive pulmonary disease. Clin Chest Med, 2014, 35:71-86.
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1. Vestbo J, Hurd SS, Agustí AG, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease:GOLD executive summary. Am J Respir Crit Care Med, 2013, 187:347-365.
2. 中华医学会呼吸病学分会肺功能专业组.肺功能检查指南-肺容量检查.中华结核和呼吸杂志, 2014, 38:255-260.
3. 中华医学会呼吸病学分会肺功能专业组.肺功能检查指南-肺弥散功能检查.中华结核和呼吸杂志, 2014, 38:163-169.
4. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南(2013年修订版).中华结核和呼吸杂志, 2013, 36:1-10.
5. 中华医学会呼吸病学分会肺功能专业组.肺功能检查指南(第二部分)-肺量计检查.中华结核和呼吸杂志, 2014, 37:481-486.
6. Rennard SI, Drummond MB. Early chronic obstructive pulmonary disease:definition, assessment, and prevention. Lancet, 2015, 385:1778-1788.
7. Ma B, Bates JH. Mechanical interactions between adjacent airways in the lung. J Appl Physiol (1985), 2014, 116:628-634.
8. Wanger J, Clausen JL, Coates A, et al. Standardisation of the measurement of lung volumes. Eur Resspir J, 2005, 26:511-522.
9. Criée CP, Sorichter S, Smith HJ, et al. Body plethysmography-its principles and clinical use. Respir Med, 2011, 105:959-971.
10. Coertjens PC, Knorst MM, Dumke A, et al. Can the single-breath helium dilution method predict lung volumes as measured by whole-body plethysmography? J Bras Pneumol, 2013, 39:675-685.
11. O'Donnell CR, Bankier AA, Stiebellehner L, et al. Comparison of plethysmographic and helium dilution lung volumes:which is best for COPD? Chest, 2010, 137:1108-1115.
12. Barnes PJ. Cellular and molecular mechanisms of chronic obstructive pulmonary disease. Clin Chest Med, 2014, 35:71-86.
13. Young IH, Bye PT. Gas exchange in disease:asthma, chronic obstructive pulmonary disease, cystic fibrosis, and interstitial lung disease. Compr Physiol, 2011, 1:663-697.

Chinese Journal of Respiratory and Critical Care Medicine

Lung Capacity and Diffusing Capacity in Patients with Chronic Obstructive Pulmonary Disease at Different Stages

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