Visual analysis of traditional Chinese medicine prescription for systemic lupus erythematosus and Sjögren syndrome based on VOSviewer software_West China Medical Journal

Authors：

GONG Bei ,  SU Li ,  SUN Ding

Department of Rheumatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P. R. China;

Corresponding author：

SU Li, Email: suli2002@vip.sina.com; SUN Ding, Email: denny.sunding@gmail.com

Keywords：

Systemic lupus erythematosus; Sjögren syndrome; law of drug use; VOSviewer; traditional Chinese medicine; data mining

DOI：

10.7507/1002-0179.202302159

Video：

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Objective To discuss the rules of using traditional Chinese medicine (TCM) to treat systemic lupus erythematosus (SLE) and Sjögren syndrome (SS). Methods The TCM prescriptions for patients with SLE or SS treated at the Department of Rheumatology of Longhua Hospital, Shanghai University of Traditional Chinese Medicine between January 2013 and July 2021 were collected. The prescriptions collected were broken down and analyzed for frequencies of the efficacies, properties, flavors and meridian tropisms of drugs in the prescriptions. The correlation and clustering analysis was performed in VOSviewer software. Results The medication information of 3689 cases of inpatients was included, from which 69167 pieces of data of using TCM prescriptions were extracted. The top 20 high-frequency drugs for treating SLE patients were mainly drugs for promoting blood circulation and removing blood stasis, qi-tonifying drugs, and drugs for heat clearing and detoxicating, which were mostly sweet, bitter or acrid in flavor, cold, warm or neutral in properties, and of the spleen, liver or stomach meridian. The drugs could be seperated into 3 clusters, the blue cluster mainly included qi-tonifying drugs, blood-tonifying drugs, and drugs for promoting blood circulation and removing blood stasis; the green cluster mainly included drugs for heat clearing and drugs for promoting blood circulation and removing blood stasis; and the red cluster mainly consisted of drugs for promoting blood circulation and removing blood stasis, drugs for inducing diuresis and alleviating edema, drugs for dispelling wind-heat, and digestant drugs. The top 20 high-frequency drugs for treating SS patients were mainly drugs for promoting blood circulation and removing blood stasis, qi-tonifying drugs, and drugs for inducing diuresis and alleviating edema, which were mostly sweet, bitter or acrid in flavor, slightly cold, cold or warm in properties, and of the spleen, stomach or liver meridian. The drugs could be seperated into 2 clusters, the green cluster mainly consisted of yin-tonifying drugs, drugs for promoting blood circulation and removing blood stasis, and drugs for heat clearing; the red cluster mainly included qi-tonifying drugs, drugs for promoting blood circulation and removing blood stasis, and drugs for inducing diuresis and alleviating edema. Conclusions The medication for SLE is in line with the treatment principle of “supplementing qi and nourishing yin, detoxicating and removing stasis”; the medication for SS, on the other hand, agrees with the basic rule of “nourishing yin and clearing away heat, promoting body fluid to moisten dryness”. Both are based on the approach of strengthening the body resistance, which is in line with the diagnostic and treatment ideas of rheumatology department and may offer the ideas of TCM syndrome differentiation for clinical use of drugs and thereby guiding the current clinical practice.

Citation： GONG Bei, SU Li, SUN Ding. Visual analysis of traditional Chinese medicine prescription for systemic lupus erythematosus and Sjögren syndrome based on VOSviewer software. West China Medical Journal, 2023, 38(6): 884-891. doi: 10.7507/1002-0179.202302159 Copy

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2.	徐愿, 罗静, 韩曼, 等. 中医药治疗风湿免疫领域临床优势病种的探讨. 中国实验方剂学杂志, 2022, 28(9): 198-204.
3.	王翎晟, 贺娟. 《黄帝内经》“正气”概念内涵辨析. 北京中医药大学学报, 2020, 43(6): 469-474.
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5.	杨晔颖, 周珺, 茅建春, 等. 补肾活血膏方对强直性脊柱炎疾病活动影响研究. 中医药学报, 2021, 49(3): 34-38.
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15.	徐洋, 高明利. 中西医治疗干燥综合征概述. 实用中医内科杂志, 2020, 34(4): 17-20.
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18.	曹佐媛, 周珺, 曲环汝. 干燥综合征中医证候研究进展. 上海中医药大学学报, 2014, 28(4): 103-105.
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20.	柳文, 张庆华, 郭圆. 陈湘君运用补阴法治疗干燥综合征经验初探. 上海中医药杂志, 2015, 49(9): 1-2.
21.	罗雅文, 刘英. 刘英教授基于“伏毒学说”辨治干燥综合征经验. 中国医药导报, 2022, 19(3): 115-118.
22.	刘萍. 酸甘化阴配伍临证应用规律探讨. 中医杂志, 2019, 60(11): 986-987.

1. 张兰予, 王春滨, 于静静, 等. 系统性红斑狼疮重叠干燥综合征合并肺部曲霉菌感染 1 例报告. 第二军医大学学报, 2014, 35(10): 1176-1177.
2. 徐愿, 罗静, 韩曼, 等. 中医药治疗风湿免疫领域临床优势病种的探讨. 中国实验方剂学杂志, 2022, 28(9): 198-204.
3. 王翎晟, 贺娟. 《黄帝内经》“正气”概念内涵辨析. 北京中医药大学学报, 2020, 43(6): 469-474.
4. 陈明. 大数据可视化分析. 计算机教育, 2015, 13(5): 94-97.
5. 杨晔颖, 周珺, 茅建春, 等. 补肾活血膏方对强直性脊柱炎疾病活动影响研究. 中医药学报, 2021, 49(3): 34-38.
6. 顾军花, 茅建春. 陈湘君运用扶正法治疗强直性脊柱炎经验撷菁. 上海中医药杂志, 2008, 42(3): 16-17.
7. 徐翔峰, 向珍蛹, 曲环汝, 等. 苏励辨治强直性脊柱炎经验案 1 则. 上海中医药杂志, 2011, 45(4): 22-24.
8. 国家药典委员会. 中华人民共和国药典: 一部. 北京: 中国医药科技出版社, 2015.
9. 中华医学会风湿病学分会. 系统性红斑狼疮诊断及治疗指南. 中华风湿病学杂志, 2010, 14(5): 342-346.
10. Feng Y, Yang M, Wu H, et al. The pathological role of B cells in systemic lupus erythematosus: from basic research to clinical. Autoimmunity, 2020, 53(2): 56-64.
11. 吕芹, 梁卡军, 李凯, 等. 《金匮要略》阴阳毒证治发挥. 时珍国医国药, 2021, 32(9): 2218-2219.
12. 姚重华, 曲环汝. 苏励教授治疗系统性红斑狼疮经验介绍. 新中医, 2009, 41(6): 10-11.
13. 陈薇薇, 苏励. 苏励从脾肾论治系统性红斑狼疮经验. 上海中医药杂志, 2019, 53(6): 24-27.
14. 徐冬, 吕晓伟, 崔鹏, 等. 艾拉莫德与羟氯喹治疗干燥综合征患者疗效及安全性比较. 疑难病杂志, 2017, 16(9): 915-918.
15. 徐洋, 高明利. 中西医治疗干燥综合征概述. 实用中医内科杂志, 2020, 34(4): 17-20.
16. 刘河间. 素问玄机原病式. 北京: 中国医药科技出版社, 2011: 47.
17. 李永明, 薛鸾. 养阴生津法为主治疗干燥综合征临床进展. 中医学报, 2019, 34(10): 2113-2118.
18. 曹佐媛, 周珺, 曲环汝. 干燥综合征中医证候研究进展. 上海中医药大学学报, 2014, 28(4): 103-105.
19. 王贵帮, 吴振起. 从“秋燥”探析清燥救肺汤制方特点. 中华中医药学刊, 2018, 36(1): 163-165.
20. 柳文, 张庆华, 郭圆. 陈湘君运用补阴法治疗干燥综合征经验初探. 上海中医药杂志, 2015, 49(9): 1-2.
21. 罗雅文, 刘英. 刘英教授基于“伏毒学说”辨治干燥综合征经验. 中国医药导报, 2022, 19(3): 115-118.
22. 刘萍. 酸甘化阴配伍临证应用规律探讨. 中医杂志, 2019, 60(11): 986-987.

West China Medical Journal

Visual analysis of traditional Chinese medicine prescription for systemic lupus erythematosus and Sjögren syndrome based on VOSviewer software

Abstract Full text Figures/Tables Video References Cited by

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