Application progress of contrast-enhanced ultrasonography in the diagnosis of gallbladder polypoid lesions_West China Medical Journal

Authors：

REN Youxiang , CAO Jiazhi ,  LING Wenwu , LUO Yan

Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

LING Wenwu, Email: lingwenwubing@163.com

Keywords：

Contrast-enhanced ultrasound; gallbladder polypoid lesion; ultrasound; gallbladder

DOI：

10.7507/1002-0179.202204088

Video：

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Gallbladder polypoid lesion (GPL) is a common gallbladder disease, mainly including tumor lesions such as gallbladder cancer and gallbladder adenoma and non-tumor lesions such as cholesterol polyps and gallbladder adenomyomatosis. Contrast-enhanced ultrasound (CEUS) can improve the diagnostic accuracy of GPL. This paper reviews the application progress of CEUS in the diagnosis of gallbladder cancer, gallbladder adenoma, gallbladder cholesterol polyps and gallbladder adenomyosis, and the limitations of CEUS in the diagnosis of GPL.

Citation： REN Youxiang, CAO Jiazhi, LING Wenwu, LUO Yan. Application progress of contrast-enhanced ultrasonography in the diagnosis of gallbladder polypoid lesions. West China Medical Journal, 2023, 38(12): 1944-1948. doi: 10.7507/1002-0179.202204088 Copy

1.	梅将军, 宋烨, 张夏静, 等. 超声造影定量分析在胆囊息肉样病变诊断中的价值. 同济大学学报(医学版), 2021, 42(4): 489-494.
2.	周锋, 王宏伟, 魏栋, 等. 超声造影检查在胆囊息肉样病变中的临床价值探讨. 肝脏, 2018, 23(1): 90-92.
3.	Xu HX. Contrast-enhanced ultrasound: the evolving applications. World J Radiol, 2009, 1(1): 15-24.
4.	曾红英, 李金莲. 超声造影诊断胆囊癌的表现特征分析. 实用肝脏病杂志, 2018, 21(4): 645-646.
5.	Reiser M, Oehmen F, Walter H, et al. Contrast enhanced ultrasound of a gallbladder lesion in a patient with a history of renal cell and rectal cancer. Case Rep Gastrointest Med, 2013, 2013: 538534.
6.	薛静, 郭静. 超声造影联合二维超声检查在厚壁型胆囊癌患者诊断中的应用价值. 河南医学研究, 2021, 30(35): 6669-6671.
7.	李茂岚, 刘颖斌. 胆囊癌诊治进展. 肝胆外科杂志, 2019, 27(5): 326-328.
8.	Wang W, Fei Y, Wang F. Meta-analysis of contrast-enhanced ultrasonography for the detection of gallbladder carcinoma. Med Ultrason, 2016, 18(3): 281-287.
9.	刘慧临, 李倩, 施胜龙, 等. 胆囊实性占位微循环灌注显像的应用研究. 影像研究与医学应用, 2022, 6(4): 28-30.
10.	金贇杰, 袁海霞, 季正标, 等. 超声造影在鉴别诊断胆囊壁弥漫增厚性疾病中的应用研究. 中国超声医学杂志, 2021, 37(6): 713-716.
11.	Badea R, Zaro R, Opincariu I, et al. Ultrasound in the examination of the gallbladder - a holistic approach: grey scale, Doppler, CEUS, elastography, and 3D. Med Ultrason, 2014, 16(4): 345-355.
12.	费翔, 罗渝昆. 胆囊超声造影指南解读与图像分析. 中华医学超声杂志(电子版), 2018, 15(1): 5-9.
13.	何晖, 任叶青, 黎昕. 不同胆囊良恶性病变超声造影征象及鉴别诊断分析. 中国超声医学杂志, 2020, 36(5): 440-444.
14.	Sparchez Z, Radu P. Role of CEUS in the diagnosis of gallbladder disease. Med Ultrason, 2012, 14(4): 326-330.
15.	Yuan HX, Wang WP, Wen JX, et al. Xanthogranulomatous cholecystitis: Contrast-Enhanced Ultrasound features and differential diagnosis from wall-thickening gallbladder carcinoma. Discov Med, 2016, 21(114): 89-98.
16.	张道建, 张德祥, 王吉文, 等. 超声造影对胆囊癌与黄色肉芽肿性胆囊炎的鉴别诊断价值. 外科理论与实践, 2020, 25(4): 322-325.
17.	Serra C, Felicani C, Mazzotta E, et al. CEUS in the differential diagnosis between biliary sludge, benign lesions and malignant lesions. J Ultrasound, 2018, 21(2): 119-126.
18.	Cheng Y, Wang M, Ma B, et al. Potential role of contrast-enhanced ultrasound for the differentiation of malignant and benign gallbladder lesions in East Asia: a meta-analysis and systematic review. Medicine (Baltimore), 2018, 97(33): e11808.
19.	Zhang HP, Bai M, Gu JY, et al. Value of contrast-enhanced ultrasound in the differential diagnosis of gallbladder lesion. World J Gastroenterol, 2018, 24(6): 744-751.
20.	Wang H, Ling W, Luo Y. Contrast-enhanced ultrasound findings of gallbladder adenocarcinoma with sarcomatoid carcinoma accompanied by intrahepatic metastasis: a case report and literature review. Medicine (Baltimore), 2018, 97(21): e10773.
21.	张贇和. 胆囊隆起性病变的致病危险因素分析及其影像学诊断. 上海: 上海交通大学, 2015.
22.	Miwa H, Numata K, Sugimori K, et al. Differential diagnosis of gallbladder polypoid lesions using contrast-enhanced ultrasound. Abdom Radiol (NY), 2019, 44(4): 1367-1378.
23.	朱连华, 费翔, 韩鹏, 等. 超声造影在胆固醇性息肉和胆囊腺瘤中的鉴别诊断价值. 中国医学科学院学报, 2021, 43(3): 350-356.
24.	黄雪兰, 邹晓娉, 薛晶心, 等. 胆囊腺瘤超声造影表现. 微量元素与健康研究, 2017, 34(6): 12-13.
25.	徐菱遥, 姜社甜. 彩超与超声造影诊断胆囊腺瘤性息肉与大型胆固醇息肉的价值. 华夏医学, 2021, 34(6): 30-33.
26.	Sun LP, Guo LH, Xu HX, et al. Value of contrast-enhanced ultrasound in the differential diagnosis between gallbladder adenoma and gallbladder adenoma canceration. Int J Clin Exp Med, 2015, 8(1): 1115-1121.
27.	Inui K, Yoshino J, Miyoshi H. Diagnosis of gallbladder tumors. Intern Med, 2011, 50(11): 1133-1136.
28.	李玉玲, 赵迎忠, 帕提玛. 超声造影在胆囊胆固醇性息肉诊断中的临床应用价值. 现代医用影像学, 2014, 23(3): 207-211.
29.	刘雪松, 李凤华, 顾莉红, 等. 胆囊胆固醇息肉的超声造影特点分析//中国超声医学工程学会. 中国超声医学工程学会成立 30 周年暨第十二届全国超声医学学术大会论文汇编. 北京: 中国超声医学工程学会, 2014: 709.
30.	Yuan Z, Liu X, Li Q, et al. Is contrast-enhanced ultrasound superior to computed tomography for differential diagnosis of gallbladder polyps? A cross-sectional study. Front Oncol, 2021, 11: 657223.
31.	王金环, 徐辉雄, 刘琳娜, 等. 胆囊腺肌增生症的超声造影表现分析. 中国临床医学影像杂志, 2016, 27(3): 177-179, 197.
32.	Bonatti M, Vezzali N, Lombardo F, et al. Gallbladder adenomyomatosis: imaging findings, tricks and pitfalls. Insights Imaging, 2017, 8(2): 243-253.
33.	张娜. CEUS 检查对胆囊腺肌症患者诊断的价值分析. 现代诊断与治疗, 2020, 31(16): 2628-2629.
34.	Tang S, Huang L, Wang Y, et al. Contrast-enhanced ultrasonography diagnosis of fundal localized type of gallbladder adenomyomatosis. BMC Gastroenterol, 2015, 15: 99.
35.	李忠轩. 超声造影对胆囊息肉样病变诊断价值探索. 天津: 天津医科大学, 2017.
36.	吴钢, 秦茜淼, 蔡端. 超声造影诊断胆囊息肉的临床价值. 肝胆胰外科杂志, 2020, 32(7): 390-394.
37.	Lin LY, Chiou HJ, Chou YH, et al. A case of tubular adenoma of gallbladder diagnosed using contrast-enhanced ultrasonography. J Med Ultrasound, 2018, 26(4): 218-221.
38.	韩鹏, 费翔, 罗渝昆, 等. 高帧频超声造影在鉴别诊断胆囊腺瘤性息肉与胆固醇性息肉中的临床应用. 中华医学超声杂志(电子版), 2020, 17(9): 815-820.
39.	田思雨, 戴婷, 孙志霞, 等. 超声造影联合超微血管成像在胆囊隆起性病变诊断中的应用. 中国实验诊断学, 2021, 25(1): 61-64.
40.	周宏莲, 刘丽娟, 叶秋荣, 等. 超声造影与 MRI 在胆囊占位性病变鉴别诊断的对比研究. 饮食保健, 2021(32): 253-254.
41.	Dong Y, Mao F, Cao J, et al. Differential diagnosis of gallbladder ascariasis debris: the added value of contrast enhanced ultrasound with high frequency transducer. Med Ultrason, 2018, 20(4): 413-419.

1. 梅将军, 宋烨, 张夏静, 等. 超声造影定量分析在胆囊息肉样病变诊断中的价值. 同济大学学报(医学版), 2021, 42(4): 489-494.
2. 周锋, 王宏伟, 魏栋, 等. 超声造影检查在胆囊息肉样病变中的临床价值探讨. 肝脏, 2018, 23(1): 90-92.
3. Xu HX. Contrast-enhanced ultrasound: the evolving applications. World J Radiol, 2009, 1(1): 15-24.
4. 曾红英, 李金莲. 超声造影诊断胆囊癌的表现特征分析. 实用肝脏病杂志, 2018, 21(4): 645-646.
5. Reiser M, Oehmen F, Walter H, et al. Contrast enhanced ultrasound of a gallbladder lesion in a patient with a history of renal cell and rectal cancer. Case Rep Gastrointest Med, 2013, 2013: 538534.
6. 薛静, 郭静. 超声造影联合二维超声检查在厚壁型胆囊癌患者诊断中的应用价值. 河南医学研究, 2021, 30(35): 6669-6671.
7. 李茂岚, 刘颖斌. 胆囊癌诊治进展. 肝胆外科杂志, 2019, 27(5): 326-328.
8. Wang W, Fei Y, Wang F. Meta-analysis of contrast-enhanced ultrasonography for the detection of gallbladder carcinoma. Med Ultrason, 2016, 18(3): 281-287.
9. 刘慧临, 李倩, 施胜龙, 等. 胆囊实性占位微循环灌注显像的应用研究. 影像研究与医学应用, 2022, 6(4): 28-30.
10. 金贇杰, 袁海霞, 季正标, 等. 超声造影在鉴别诊断胆囊壁弥漫增厚性疾病中的应用研究. 中国超声医学杂志, 2021, 37(6): 713-716.
11. Badea R, Zaro R, Opincariu I, et al. Ultrasound in the examination of the gallbladder - a holistic approach: grey scale, Doppler, CEUS, elastography, and 3D. Med Ultrason, 2014, 16(4): 345-355.
12. 费翔, 罗渝昆. 胆囊超声造影指南解读与图像分析. 中华医学超声杂志(电子版), 2018, 15(1): 5-9.
13. 何晖, 任叶青, 黎昕. 不同胆囊良恶性病变超声造影征象及鉴别诊断分析. 中国超声医学杂志, 2020, 36(5): 440-444.
14. Sparchez Z, Radu P. Role of CEUS in the diagnosis of gallbladder disease. Med Ultrason, 2012, 14(4): 326-330.
15. Yuan HX, Wang WP, Wen JX, et al. Xanthogranulomatous cholecystitis: Contrast-Enhanced Ultrasound features and differential diagnosis from wall-thickening gallbladder carcinoma. Discov Med, 2016, 21(114): 89-98.
16. 张道建, 张德祥, 王吉文, 等. 超声造影对胆囊癌与黄色肉芽肿性胆囊炎的鉴别诊断价值. 外科理论与实践, 2020, 25(4): 322-325.
17. Serra C, Felicani C, Mazzotta E, et al. CEUS in the differential diagnosis between biliary sludge, benign lesions and malignant lesions. J Ultrasound, 2018, 21(2): 119-126.
18. Cheng Y, Wang M, Ma B, et al. Potential role of contrast-enhanced ultrasound for the differentiation of malignant and benign gallbladder lesions in East Asia: a meta-analysis and systematic review. Medicine (Baltimore), 2018, 97(33): e11808.
19. Zhang HP, Bai M, Gu JY, et al. Value of contrast-enhanced ultrasound in the differential diagnosis of gallbladder lesion. World J Gastroenterol, 2018, 24(6): 744-751.
20. Wang H, Ling W, Luo Y. Contrast-enhanced ultrasound findings of gallbladder adenocarcinoma with sarcomatoid carcinoma accompanied by intrahepatic metastasis: a case report and literature review. Medicine (Baltimore), 2018, 97(21): e10773.
21. 张贇和. 胆囊隆起性病变的致病危险因素分析及其影像学诊断. 上海: 上海交通大学, 2015.
22. Miwa H, Numata K, Sugimori K, et al. Differential diagnosis of gallbladder polypoid lesions using contrast-enhanced ultrasound. Abdom Radiol (NY), 2019, 44(4): 1367-1378.
23. 朱连华, 费翔, 韩鹏, 等. 超声造影在胆固醇性息肉和胆囊腺瘤中的鉴别诊断价值. 中国医学科学院学报, 2021, 43(3): 350-356.
24. 黄雪兰, 邹晓娉, 薛晶心, 等. 胆囊腺瘤超声造影表现. 微量元素与健康研究, 2017, 34(6): 12-13.
25. 徐菱遥, 姜社甜. 彩超与超声造影诊断胆囊腺瘤性息肉与大型胆固醇息肉的价值. 华夏医学, 2021, 34(6): 30-33.
26. Sun LP, Guo LH, Xu HX, et al. Value of contrast-enhanced ultrasound in the differential diagnosis between gallbladder adenoma and gallbladder adenoma canceration. Int J Clin Exp Med, 2015, 8(1): 1115-1121.
27. Inui K, Yoshino J, Miyoshi H. Diagnosis of gallbladder tumors. Intern Med, 2011, 50(11): 1133-1136.
28. 李玉玲, 赵迎忠, 帕提玛. 超声造影在胆囊胆固醇性息肉诊断中的临床应用价值. 现代医用影像学, 2014, 23(3): 207-211.
29. 刘雪松, 李凤华, 顾莉红, 等. 胆囊胆固醇息肉的超声造影特点分析//中国超声医学工程学会. 中国超声医学工程学会成立 30 周年暨第十二届全国超声医学学术大会论文汇编. 北京: 中国超声医学工程学会, 2014: 709.
30. Yuan Z, Liu X, Li Q, et al. Is contrast-enhanced ultrasound superior to computed tomography for differential diagnosis of gallbladder polyps? A cross-sectional study. Front Oncol, 2021, 11: 657223.
31. 王金环, 徐辉雄, 刘琳娜, 等. 胆囊腺肌增生症的超声造影表现分析. 中国临床医学影像杂志, 2016, 27(3): 177-179, 197.
32. Bonatti M, Vezzali N, Lombardo F, et al. Gallbladder adenomyomatosis: imaging findings, tricks and pitfalls. Insights Imaging, 2017, 8(2): 243-253.
33. 张娜. CEUS 检查对胆囊腺肌症患者诊断的价值分析. 现代诊断与治疗, 2020, 31(16): 2628-2629.
34. Tang S, Huang L, Wang Y, et al. Contrast-enhanced ultrasonography diagnosis of fundal localized type of gallbladder adenomyomatosis. BMC Gastroenterol, 2015, 15: 99.
35. 李忠轩. 超声造影对胆囊息肉样病变诊断价值探索. 天津: 天津医科大学, 2017.
36. 吴钢, 秦茜淼, 蔡端. 超声造影诊断胆囊息肉的临床价值. 肝胆胰外科杂志, 2020, 32(7): 390-394.
37. Lin LY, Chiou HJ, Chou YH, et al. A case of tubular adenoma of gallbladder diagnosed using contrast-enhanced ultrasonography. J Med Ultrasound, 2018, 26(4): 218-221.
38. 韩鹏, 费翔, 罗渝昆, 等. 高帧频超声造影在鉴别诊断胆囊腺瘤性息肉与胆固醇性息肉中的临床应用. 中华医学超声杂志(电子版), 2020, 17(9): 815-820.
39. 田思雨, 戴婷, 孙志霞, 等. 超声造影联合超微血管成像在胆囊隆起性病变诊断中的应用. 中国实验诊断学, 2021, 25(1): 61-64.
40. 周宏莲, 刘丽娟, 叶秋荣, 等. 超声造影与 MRI 在胆囊占位性病变鉴别诊断的对比研究. 饮食保健, 2021(32): 253-254.
41. Dong Y, Mao F, Cao J, et al. Differential diagnosis of gallbladder ascariasis debris: the added value of contrast enhanced ultrasound with high frequency transducer. Med Ultrason, 2018, 20(4): 413-419.

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