The efficacy and safety of glucosamine hydrochloride tablets on uremia patients with knee osteoarthritis_West China Medical Journal

Authors：

 GU Jinhua , ZHAO Ping , WU Yalin

Department of Rheumatology and Immunology, the Second People’s Hospital of Yibin City, Yibin, Sichuan 644000, P. R. China;

Corresponding author：

GU Jinhua, Email: gujinhua120@163.com

Keywords：

Glucosamine hydrochloride tablets; Uremia; Knee osteoarthritis; Therapeutic effect; Safety

DOI：

10.7507/1002-0179.201608162

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To observe the treatment efficacy and safety of glucosamine hydrochloride tablets on uremia patients with knee osteoarthritis (OA). Methods A total of 118 uremia patients with knee OA were selected and randomly divided into the glucosamine hydrochloride tablets treatment group (treatment group) and the coated aldehyde oxystarch capsules group (control group) with 59 cases in each group. The course was 8 weeks. The Lequesne Index was assessed for curative effect evaluation, and the change of blood indexes was observed to evaluate drug safety. Results The total effective rate of Lequesne Index in the treatment group was 72.9%, while that in the control group was 13.6%; the difference was statistically significant (χ²=42.303, P<0.001). There was no significant change in the two groups before and after treatment in terms of the patients’ dialysis adequacy, routine blood, blood electrolytes, liver and kidney function (P>0.05). Conclusion Glucosamine hydrochloride tablets is curative and safe in the treatment of uremia patients with OA.

Citation： GU Jinhua, ZHAO Ping, WU Yalin. The efficacy and safety of glucosamine hydrochloride tablets on uremia patients with knee osteoarthritis. West China Medical Journal, 2017, 32(8): 1217-1220. doi: 10.7507/1002-0179.201608162 Copy

1.	中华医学会风湿病学分会. 骨关节炎诊断及治疗指南. 中华风湿病学杂志, 2010, 14(6): 416-419.
2.	胥少汀, 葛宝丰, 徐印坎. 实用骨科学. 北京: 人民军医出版社, 2010: 259-1339.
3.	Valdes AM, Spector TD. The genetic epidemiology of osteoarthritis. Curr Opin Rheumatol, 2010, 22(2): 139-143.
4.	Sanchez C, Mateus MM, Defresne MP, et al. Metabolism of human articular chondrocytes cultured in alginate beads. Longterm efects of interleukin 1 beta and nonsteroidal antiinflam-matory drugs. J Rheumatol, 2002, 29(4): 772-782.
5.	冷艳霞, 孙璐, 邸欣, 等. 盐酸氨基葡萄糖片的相对生物利用度及其生物等效性评价. 沈阳药科大学学报, 2006, 23(1): 6-9, 37.
6.	郑昱新, 曹月龙, 石关桐, 等. 氨基葡萄糖对体外培养人软骨和滑膜细胞软骨寡聚基质蛋白分泌影响的比较. 中华风湿病学杂志, 2009, 13(5): 331-332.
7.	Barthe L, Woodley J, Lavit M, et al. In vitro intestinal degradation and absorption of chondroitin sulfate, a glycosaminoglycan drug. Arzneimittelforschung, 2004, 54(5): 286-292.
8.	Aghazadeh-Habashi A, Jamali F. The glucosamine controversy; a pharmacokinetic issue. J Pharm Pharm Sci, 2011, 14(2): 264-273.
9.	鲍运平, 易洋, 彭礼林, 等. 氨基葡萄糖对膝骨关节炎 SOD、MDA 影响的临床研究. 长江大学学报: 自科版医学下旬刊, 2013, 10(10): 1-2, 5.
10.	鲍运平, 喻爱喜, 杜娟, 等. 氨基葡萄糖对膝骨关节炎白细胞介素-6、血管内皮细胞生长因子影响的临床研究. 临床外科杂志, 2013, 21(1): 60-61.
11.	薛铮, 陈亚堃, 钱钧强. 盐酸氨基葡萄糖对膝骨关节炎患者关节液中 SOD 和 MDA 水平的影响. 中国药师, 2012, 15(4): 540-542.
12.	罗从风, 曾炳芳. 硫酸氨基葡萄糖治疗骨关节炎的临床观察. 国外医学: 骨科学分册, 2001, 22(3): 174.
13.	张鹏, 郑昱新, 曹月龙, 等. 布洛芬与氨基葡萄糖对膝骨关节炎患者滑膜细胞增殖及软骨寡聚基质蛋白表达影响的比较. 中华风湿病学杂志, 2010, 14(10): 668-671.
14.	Richy F, Bruyere O, Ethgen O, et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Arch Intern Med, 2003, 163(13): 1514-1522.
15.	杨南萍, 李江涛, 王玲, 等. 国产盐酸氨基葡萄糖片治疗膝骨性关节炎临床观察. 华西医学, 2004, 19(4): 544-545.

1. 中华医学会风湿病学分会. 骨关节炎诊断及治疗指南. 中华风湿病学杂志, 2010, 14(6): 416-419.
2. 胥少汀, 葛宝丰, 徐印坎. 实用骨科学. 北京: 人民军医出版社, 2010: 259-1339.
3. Valdes AM, Spector TD. The genetic epidemiology of osteoarthritis. Curr Opin Rheumatol, 2010, 22(2): 139-143.
4. Sanchez C, Mateus MM, Defresne MP, et al. Metabolism of human articular chondrocytes cultured in alginate beads. Longterm efects of interleukin 1 beta and nonsteroidal antiinflam-matory drugs. J Rheumatol, 2002, 29(4): 772-782.
5. 冷艳霞, 孙璐, 邸欣, 等. 盐酸氨基葡萄糖片的相对生物利用度及其生物等效性评价. 沈阳药科大学学报, 2006, 23(1): 6-9, 37.
6. 郑昱新, 曹月龙, 石关桐, 等. 氨基葡萄糖对体外培养人软骨和滑膜细胞软骨寡聚基质蛋白分泌影响的比较. 中华风湿病学杂志, 2009, 13(5): 331-332.
7. Barthe L, Woodley J, Lavit M, et al. In vitro intestinal degradation and absorption of chondroitin sulfate, a glycosaminoglycan drug. Arzneimittelforschung, 2004, 54(5): 286-292.
8. Aghazadeh-Habashi A, Jamali F. The glucosamine controversy; a pharmacokinetic issue. J Pharm Pharm Sci, 2011, 14(2): 264-273.
9. 鲍运平, 易洋, 彭礼林, 等. 氨基葡萄糖对膝骨关节炎 SOD、MDA 影响的临床研究. 长江大学学报: 自科版医学下旬刊, 2013, 10(10): 1-2, 5.
10. 鲍运平, 喻爱喜, 杜娟, 等. 氨基葡萄糖对膝骨关节炎白细胞介素-6、血管内皮细胞生长因子影响的临床研究. 临床外科杂志, 2013, 21(1): 60-61.
11. 薛铮, 陈亚堃, 钱钧强. 盐酸氨基葡萄糖对膝骨关节炎患者关节液中 SOD 和 MDA 水平的影响. 中国药师, 2012, 15(4): 540-542.
12. 罗从风, 曾炳芳. 硫酸氨基葡萄糖治疗骨关节炎的临床观察. 国外医学: 骨科学分册, 2001, 22(3): 174.
13. 张鹏, 郑昱新, 曹月龙, 等. 布洛芬与氨基葡萄糖对膝骨关节炎患者滑膜细胞增殖及软骨寡聚基质蛋白表达影响的比较. 中华风湿病学杂志, 2010, 14(10): 668-671.
14. Richy F, Bruyere O, Ethgen O, et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Arch Intern Med, 2003, 163(13): 1514-1522.
15. 杨南萍, 李江涛, 王玲, 等. 国产盐酸氨基葡萄糖片治疗膝骨性关节炎临床观察. 华西医学, 2004, 19(4): 544-545.

West China Medical Journal

The efficacy and safety of glucosamine hydrochloride tablets on uremia patients with knee osteoarthritis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content