Influence of Anti-syphilis Treatment on Pregnancy Outcome and Neonatal Prognosis_West China Medical Journal

Authors：

 LINKeng

Department of Clinical Laboratory, Women and Children's Hospital of Huadu District, Guangzhou, Guangdong 510800, P. R. China;

Corresponding author：

Keywords：

Anti-syphilis; Pregnancy; Pregnancy outcome; Neonatal prognosis

DOI：

10.7507/1002-0179.20140388

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Objective To explore the influence of treatment against syphilis on pregnancy outcome and neonatal prognosis. Methods The data of 5224 cases of pregnant women from January to December 2013 were analyzed. All the pregnant women were screened by toluidine red unheated serum test (TRUST) method. Then, T.pallidum passive partideag glutining assay (TPPA) was used to confirm those positive cases from TRUST. At last, 128 cases of syphilis in those pregnant women were confirmed. According to whether the pregnant women accepted antenatal examination and treatment, they were divided into treatment group and non-treatment group. The pregnancy outcome and neonatal prognosis of these two groups of women were then compared and analyzed. Results The pregnancy outcome of these two groups had comparatively big difference, but without significant difference (χ²=3.34, P>0.05). The neonatal prognosis of the two groups was significantly different (χ²=9.14, P<0.05). Moreover, TPPA showed positive in all newborn infants, and TURST showed 85 positive cases. Conclusion Early finding and treatment of pregnant women with syphilis by screening before pregnancy or during the early period of pregnancy can reduce abortion, stillbirth, fetal abnormalities, and the incidence of neonatal congenital syphilis.

Citation： LINKeng. Influence of Anti-syphilis Treatment on Pregnancy Outcome and Neonatal Prognosis. West China Medical Journal, 2014, 29(7): 1267-1270. doi: 10.7507/1002-0179.20140388 Copy

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1. 王临虹, 王玲, 王爱玲, 等. 先天梅毒防治指南(一)[J]. 中国妇幼卫生杂志, 2010, l(4):185-188.
2. 王临虹, 王玲, 王爱玲, 等. 先天梅毒防治指南(二)[J]. 中国妇幼卫生杂志, 2010, 1(5):238-244.
3. 袁柳. 探讨三种梅毒血清学检验方法的临床应用[J]. 中国医药指南, 2013, 11(2):241-242.
4. 于恩庶, 邵康蔚, 原寿基. 艾滋病与性病学[M]. 厦门:厦门大学出版社, 1993:363-364.
5. 刘冬先, 陈兴平, 周礼义. 先天梅毒43例临床分析及预防探讨[J]. 中国麻风皮肤病杂志, 2004, 20(5):461-462.
6. 王千秋, 张国成. 性传播疾病临床诊疗指南[M]. 上海:上海科学技术出版社, 2007:1-2.
7. 冯永芳, 曾志良, 黄萌, 等. 一家三口同患梅毒[J]. 中国皮肤性病学杂志, 2009, 23(6):366-367.
8. 周敏, 陈竹, 曾义岚, 等. 抗梅毒治疗对妊娠结局及新生儿预后的影响[J]. 中华临床感染病杂志, 2013, 6(4):226-228.
9. 粱岚. 妊娠期梅毒68例临床分析[J]. 中国实用医药, 2009, 4(8):100-101.
10. Peeling RW, Ye H. Diagnostic tools for preventing and managing maternal and congenital syphilis:an overview[J]. Bull World Health Organ, 2004, 82(6):439-446.
11. 曹志君, 王伟民, 黄慧娟, 等. 妊娠期梅毒患者围产结局的临床分析[J]. 中华妇产科杂志, 2011, 36(3):170-171.
12. 陈涵强, 杨斌, 张尔泉. 52例新生儿梅毒临床观察[J]. 中华围产医学杂志, 1999, 2(4):255.
13. 王红兵, 丘瑾, 潘群. 抗梅毒治疗对妊娠合并梅毒孕妇及胎儿的影响[J]. 同济大学学报·医学版, 2003, 24(5):449-451.
14. 樊尚荣, 董悦. 妊娠合并梅毒[J]. 中华围产医学杂志, 1998, 1(3):190-192.
15. 刘小平, 樊尚荣. 妊娠期抗梅毒治疗后新生儿先天梅毒[J]. 国外医学·妇产科学分册, 2003, 30(2):126-127.
16. 吴瑞萍, 胡亚美, 江载芳, 等. 实用儿科学[M]. 6版. 北京:人民卫生出版社, 1995:980-985.

West China Medical Journal

Influence of Anti-syphilis Treatment on Pregnancy Outcome and Neonatal Prognosis

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