Ultrasound and Pathological Analysis of Intrauterine Residual Tissue in Patients with Vaginal Bleeding after Drug Abortion_West China Medical Journal

Authors：

 YAOAi-jing ¹ , GAODa-wei ²

1. Department of Gynaecology and Obstetrics, the Eighth Hospital of Tangshan, Tangshan, Hebei 063000, P. R. China;
2. the Woman and Children Hospital of Tangshan, Tangshan, Hebei, 063000, P. R. China;

Corresponding author：

Keywords：

Prolonged bleeding; Intrauterine residue; Ultrasound; Pathology

DOI：

10.7507/1002-0179.20140280

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To examine the intrauterine residual tissue in patients with prolonged vaginal bleeding after drug abortion by both B-ultrasound and pathology through cleaning the remnant of uterine, in order to investigate the relationship between prolonged vaginal bleeding after medical abortion with mifepristone and the residual tissues (decidua/villi). Methods Between June and December 2011, 144 patients with vaginal bleeding after medical abortion were involved in the study. B-ultrasound and pathology through cleaning the remnant of uterine were adopted to study the residual tissue respectively. Results Based on the ultrasound results, the difference in residual tissues was statistically significant between patients with bleeding for 15 days or shorter and patients with bleeding for more than 15 days (P<0.05). The pathological results showed that the difference in decidua and villi on the residual tissues was not statistically significant between patients with bleeding for 15 days or shorter and patients with bleeding for more than 15 days (P>0.05). Conclusion After drug abortion, the prolonged vaginal bleeding was correlated with intrauterine residual tissues, and was not correlated with whether the residual tissue was villi or decidua.

Citation： YAOAi-jing, GAODa-wei. Ultrasound and Pathological Analysis of Intrauterine Residual Tissue in Patients with Vaginal Bleeding after Drug Abortion. West China Medical Journal, 2014, 29(5): 925-927. doi: 10.7507/1002-0179.20140280 Copy

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9.	Angela D. The efficacy and tolerance of mifepristone and prostaglandin in termination of pregnancy of less than 63 days gestation; UK Multicentre Study-final results[J]. Contraception, 1997, 55(1):1-5.
10.	张艳, 高尔生, 朱虔兮, 等. 米非司酮药物流产与继后妊娠产后出血的研究[J]. 中国实用妇科与产科杂志, 2008, 24(5):351-353.
11.	郑波. 两例药物流产大出血中缩宫素应用不当分析[J]. 中国实用医药, 2012, 7(16):167-168.
12.	童传良, 庄留琪. 药物流产的安全性与评价[J]. 中国实用妇科与产科杂志, 2000, 16(10):588-590.
13.	张云竹, 于燕, 吴燕虹. 药物流产后出血的原因中西医研究进展[J]. 辽宁中医药大学学报, 2008, 10(12):179-181.
14.	桑国卫, 翁黎驹, 邵庆翔, 等. 不同剂量米非司酮和米索前列醇终止早孕的临床研究[J]. 中华妇产科杂志, 1994, 29(12):735-738, 763.
15.	李瑞珍, 王振海, 吴瑞芳, 等. 米非司酮配伍米索前列醇抗早孕蜕膜与绒毛细胞凋亡及其调控基因的研究[J]. 中华妇产科杂志, 1999, 34(5):24-26.

1. Løkeland M, Iversen OE, Dahle GS, et al. Medical abortion at 63 to 90 days of gestation[J]. Obstet Gynecol, 2010, 115(5):962-968.
2. 乐杰. 妇产科学[M]. 北京:人民卫生出版社, 2008:374-375.
3. 韩向阳, 孙敬霞, 韩燕燕. 药物流产并发症的种类处理和预防[J]. 中国实用妇科与产科杂志, 2000, 16(10):590-592.
4. 顾向应, 李丽, 范庆春, 等. 早孕药物流产时米非司酮剂量和不同作用时间对蜕膜类固醇受体表达的影响[J]. 生殖与避孕, 2008, 28(8):467-470, 476.
5. Im A, Appleman LJ. Mifepristone:pharmacology and clinical impact in reproductive medicine, endocrinology and oncology[J]. Expert Opin Pharmacother, 2010, 11(3):481-488.
6. Kapp NP, Ngo TD. Cervical preparation for first trimester surgical abortion[J]. Obstet Gynecol, 2010, 115(5):1075-1076.
7. 翁梨驹. 米非司酮配伍前列腺素终止妊娠8~12周的流产问题[J]. 中国实用妇科与产科杂志, 2000, 16(10):9-11.
8. 赖文瑶. 药物流产和人工流产对再次妊娠各期并发症影响的比较[J]. 广东医学院学报, 2002, 20(1):53-57.
9. Angela D. The efficacy and tolerance of mifepristone and prostaglandin in termination of pregnancy of less than 63 days gestation; UK Multicentre Study-final results[J]. Contraception, 1997, 55(1):1-5.
10. 张艳, 高尔生, 朱虔兮, 等. 米非司酮药物流产与继后妊娠产后出血的研究[J]. 中国实用妇科与产科杂志, 2008, 24(5):351-353.
11. 郑波. 两例药物流产大出血中缩宫素应用不当分析[J]. 中国实用医药, 2012, 7(16):167-168.
12. 童传良, 庄留琪. 药物流产的安全性与评价[J]. 中国实用妇科与产科杂志, 2000, 16(10):588-590.
13. 张云竹, 于燕, 吴燕虹. 药物流产后出血的原因中西医研究进展[J]. 辽宁中医药大学学报, 2008, 10(12):179-181.
14. 桑国卫, 翁黎驹, 邵庆翔, 等. 不同剂量米非司酮和米索前列醇终止早孕的临床研究[J]. 中华妇产科杂志, 1994, 29(12):735-738, 763.
15. 李瑞珍, 王振海, 吴瑞芳, 等. 米非司酮配伍米索前列醇抗早孕蜕膜与绒毛细胞凋亡及其调控基因的研究[J]. 中华妇产科杂志, 1999, 34(5):24-26.

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West China Medical Journal

Ultrasound and Pathological Analysis of Intrauterine Residual Tissue in Patients with Vaginal Bleeding after Drug Abortion

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