Application of ultra-wide-field fluorescein angiography and 7 standard field in retinal vein occlusion_Chinese Journal of Ocular Fundus Diseases

Authors：

XuA'min ,  ChenChangzheng , YiZuohuizi , QiHang , LiLu , SuYu

Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430060, China;

Corresponding author：

ChenChangzheng, Email: whuchenchzh@163.com

Keywords：

Retinal vein occlusion/diagnosis; Fluorescein angiography; Tomography, optical coherence

DOI：

10.3760/cma.j.issn.1005-1015.2017.01.006

Video：

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Objective To observe the angiographic features of patients with retinal vein occlusion (RVO) by ultra-wide-field fluorescein angiography (UWFA) and compare with the conventional 7 standard field (7SF) imaging. Methods This is a retrospective clinical description study. Fifty-eight eyes of 56 RVO patients were included. There were 25 males (26 eyes) and 31 females (32 eyes). The age ranged from 25 to 69 years, with a mean age of (48.12±18.56) years. The course of disease was from 2 days to 25 months, with a mean course of (12.78±11.35) months. Thirty eyes were diagnosed with central RVO (51.72%), 26 eyes were diagnosed with branch RVO (44.83%) and 2 eyes were diagnosed with hemicentral RVO (3.45%). Retinal laser photocoagulation was performed in 11 eyes (18.97%). All patients received examinations of UWFA (British Optomap 200Tx imaging system) and optical coherence tomography (OCT). Using the protocol for obtaining 7SF images as described in the Early Treatment Diabetic Retinopathy Study, 7 circular regions with a range of 30 degrees were combined as the 7SF template to determine the observation area. This template was then overlaid on the UWFA image to identify the potential viewable area of 7SF. The visualized retinal area, retinal non-perfusion area, retinal neovascularization area, and laser spot area of UWFA and 7SF were quantified by a retinal specialist. In addition, the OCT images of the affected eye were observed and analyzed to confirm the existence of macular edema. Correlation analysis was done between retinal non-perfusion, retinal neovascularization and macular edema detected by UWFA. Results The results of UWFA and 7SF examination were the same. Compared with 7SF, UWFA showed 3.53 times more retinal visual area, 3.31 times more non-perfusion area, 1.94 times more neovascularization area, and 3.59 times more laser spots (t=72.13, 4.69, 1.76, 5.78;P=0.000, 0.005, 0.102, 0.000). Lesions of 11 eyes (18.97%) were found outside the range of 7SF images. By UWFA, non-perfusion area correlated with neovascularization and macular edema (χ²=12.13, 4.82;P=0.000, 0.028;C=0.42, 0.28). Non-perfusion area anterior to the equator have significantly correlations with macular edema (χ²=6.32,P=0.012,C=0.31), but non-perfusion posterior to the globe equator have no relevance with macular edema (χ²=2.88,P=0.090, C=0.22). Conclusions UWFA can detect more peripheral retinal lesions than 7SF images. By UWFA, non-perfusion area has correlation with neovascularization and macular edema.

Citation： XuA'min, ChenChangzheng, YiZuohuizi, QiHang, LiLu, SuYu. Application of ultra-wide-field fluorescein angiography and 7 standard field in retinal vein occlusion. Chinese Journal of Ocular Fundus Diseases, 2017, 33(1): 19-22. doi: 10.3760/cma.j.issn.1005-1015.2017.01.006 Copy

1.	Branch Vein Occlusion Study Group. Argon laser scatter photocoagulation for prevention of neovascularization and vitreous hemorrhage in branch vein occlusion: a randomized clinical trial [J]. Arch Ophthalmol, 1986, 104(1): 34-41.
2.	Central Vein Occlusion Study Group. Natural history and clinical management of central retinal vein occlusion[J]. Arch Ophthalmol, 1997, 115(4): 486-491.
3.	Silva PS, Cavallerano JD, Sun JK, et al. Nonmydriatic ultrawide field retinal imaging compared with dilated standard 7-field 35-mm photography and retinal specialist examination for evaluation of diabetic retinopathy[J]. Am J Ophthalmol, 2012, 154(3): 549-559. DOI: 10.1016/j.ajo.2012.03.019.
4.	闫宏.荧光血管造影[M]//刘文, 文峰.临床眼底病(内科卷). 北京: 人民卫生出版社, 2015: 201-204. Yan H. Fundus fluorescein angiography [M]//Liu W, Wen F. Clinical ocular fundus disease(Internal medicine volume). Beijing: People's Medical Publishing House, 2015: 201-204.
5.	Early Treatment Diabetic Retinopathy Study Research Group. Grading diabetic retinopathy from stereoscopic color fundus photographs-an extension of the modified Airlie House classification. ETDRS report number 10[J]. Ophthalmology, 1991, 98(5 Suppl): S786-806.
6.	Friberg TR, Gupta A, Yu J, et al. Ultrawide angle fluorescein angiographic imaging: a comparison to conventional digital acquisition systems[J]. Ophthalmic Surg Lasers Imaging, 2008, 39(4): 304-311.
7.	Csutak A, Lengyel I, Jonasson F, et al. Agreement between image grading of conventional (45 degrees) and ultra wide-angle (200 degrees) digital images in the maculain the Reykjavik eye study[J]. Eye (Lond), 2010, 24(10): 1568-1575. DOI: 10.1038/eye.2010.85.
8.	Mackenzie PJ, Russell M, Ma PE, et al. Sensitivity and specificity of the optos optomap for detecting peripheral retinal lesions[J]. Retina, 2007, 27(8): 1119-1124. DOI: 10.1097/IAE.0b013e3180592b5c.
9.	McIntosh RL, Mohamed Q, Saw SM, et al.Interventions for branch retinal vein occlusion: an evidence-based systematic review[J].Ophthalmology, 2007, 114(5): 835-854. DOI: 10.1016/ j.ophtha.2007.01.010.
10.	Vinores SA, Youssri AI, Luna JD, et al. Upregulation of vascular endothelial growth factor in ischemic and non-ischemic human and experimental retinal disease[J].Histol Histopathol, 1997, 12(1): 99-109.
11.	Kaur C, Foulds WS, Ling EA. Blood-retinal barrier in hypoxic ischaemic conditions: basic concepts, clinical features and management[J]. Prog Retin Eye Res, 2008, 27(6): 622-647.DOI: 10.1016/j.preteyeres.
12.	Noma H, Funatsu H, Yamasaki M, et al. Pathogenesis of macular edema with branch retinal vein occlusion and intraocular levels of vascular endothelial growth factor and interleukin-6[J]. Am J Ophthalmol, 2005, 140(2): 256-261. DOI: 10.1016/j.ajo. 2005.03.003.
13.	Noma H, Funatsu H, Yamasaki M, et al. Aqueous humour levels of cytokines are correlated to vitreous levels and severity of macular oedema in branch retinal vein occlusion[J]. Eye, 2008, 22(1): 42-48. DOI: 10.1038/sj.eye.6702498.
14.	Noma H, Funatsu H, Mimura T, et al. Vitreous levels of interleukin-6 and vascular endothelial growth factor in macular edema with central retinal vein occlusion[J]. Ophthalmology, 2009, 116 (1): 87-93. DOI: 10.1016/j.ophtha.2008.09.034.
15.	Prasad PS, Oliver SC, Coffee RE, et al.Ultra wide-field angiographic characteristics of branch retinal and hemicentral retinal vein occlusion [J]. Ophthalmology, 2010, 117(4): 780-784. DOI: 10.1016/j.ophtha.2009.09.019.
16.	Hayreh SS. Retinal vein occlusion[J]. Indian J Ophthalmol, 1994, 42(3): 109-132.
17.	Sagong M, van Hemert J, Olmos de Koo LC, et al.Assessment of accuracy and precision of quantification of ultra-widefield images[J].Ophthalmology, 2015, 122(4): 864-866. DOI: 10.1016/j.ophtha.2014.11.016.
18.	Singer M, Sagong M, van Hemert J, et al.Ultra-widefield imaging of the peripheral retinal vasculature in normal subjects [J].Ophthalmology, 2016, 123(5): 1053-1059. DOI:10.1016/ j.Ophtha.2016.01.022.

1. Branch Vein Occlusion Study Group. Argon laser scatter photocoagulation for prevention of neovascularization and vitreous hemorrhage in branch vein occlusion: a randomized clinical trial [J]. Arch Ophthalmol, 1986, 104(1): 34-41.
2. Central Vein Occlusion Study Group. Natural history and clinical management of central retinal vein occlusion[J]. Arch Ophthalmol, 1997, 115(4): 486-491.
3. Silva PS, Cavallerano JD, Sun JK, et al. Nonmydriatic ultrawide field retinal imaging compared with dilated standard 7-field 35-mm photography and retinal specialist examination for evaluation of diabetic retinopathy[J]. Am J Ophthalmol, 2012, 154(3): 549-559. DOI: 10.1016/j.ajo.2012.03.019.
4. 闫宏.荧光血管造影[M]//刘文, 文峰.临床眼底病(内科卷). 北京: 人民卫生出版社, 2015: 201-204. Yan H. Fundus fluorescein angiography [M]//Liu W, Wen F. Clinical ocular fundus disease(Internal medicine volume). Beijing: People's Medical Publishing House, 2015: 201-204.
5. Early Treatment Diabetic Retinopathy Study Research Group. Grading diabetic retinopathy from stereoscopic color fundus photographs-an extension of the modified Airlie House classification. ETDRS report number 10[J]. Ophthalmology, 1991, 98(5 Suppl): S786-806.
6. Friberg TR, Gupta A, Yu J, et al. Ultrawide angle fluorescein angiographic imaging: a comparison to conventional digital acquisition systems[J]. Ophthalmic Surg Lasers Imaging, 2008, 39(4): 304-311.
7. Csutak A, Lengyel I, Jonasson F, et al. Agreement between image grading of conventional (45 degrees) and ultra wide-angle (200 degrees) digital images in the maculain the Reykjavik eye study[J]. Eye (Lond), 2010, 24(10): 1568-1575. DOI: 10.1038/eye.2010.85.
8. Mackenzie PJ, Russell M, Ma PE, et al. Sensitivity and specificity of the optos optomap for detecting peripheral retinal lesions[J]. Retina, 2007, 27(8): 1119-1124. DOI: 10.1097/IAE.0b013e3180592b5c.
9. McIntosh RL, Mohamed Q, Saw SM, et al.Interventions for branch retinal vein occlusion: an evidence-based systematic review[J].Ophthalmology, 2007, 114(5): 835-854. DOI: 10.1016/ j.ophtha.2007.01.010.
10. Vinores SA, Youssri AI, Luna JD, et al. Upregulation of vascular endothelial growth factor in ischemic and non-ischemic human and experimental retinal disease[J].Histol Histopathol, 1997, 12(1): 99-109.
11. Kaur C, Foulds WS, Ling EA. Blood-retinal barrier in hypoxic ischaemic conditions: basic concepts, clinical features and management[J]. Prog Retin Eye Res, 2008, 27(6): 622-647.DOI: 10.1016/j.preteyeres.
12. Noma H, Funatsu H, Yamasaki M, et al. Pathogenesis of macular edema with branch retinal vein occlusion and intraocular levels of vascular endothelial growth factor and interleukin-6[J]. Am J Ophthalmol, 2005, 140(2): 256-261. DOI: 10.1016/j.ajo. 2005.03.003.
13. Noma H, Funatsu H, Yamasaki M, et al. Aqueous humour levels of cytokines are correlated to vitreous levels and severity of macular oedema in branch retinal vein occlusion[J]. Eye, 2008, 22(1): 42-48. DOI: 10.1038/sj.eye.6702498.
14. Noma H, Funatsu H, Mimura T, et al. Vitreous levels of interleukin-6 and vascular endothelial growth factor in macular edema with central retinal vein occlusion[J]. Ophthalmology, 2009, 116 (1): 87-93. DOI: 10.1016/j.ophtha.2008.09.034.
15. Prasad PS, Oliver SC, Coffee RE, et al.Ultra wide-field angiographic characteristics of branch retinal and hemicentral retinal vein occlusion [J]. Ophthalmology, 2010, 117(4): 780-784. DOI: 10.1016/j.ophtha.2009.09.019.
16. Hayreh SS. Retinal vein occlusion[J]. Indian J Ophthalmol, 1994, 42(3): 109-132.
17. Sagong M, van Hemert J, Olmos de Koo LC, et al.Assessment of accuracy and precision of quantification of ultra-widefield images[J].Ophthalmology, 2015, 122(4): 864-866. DOI: 10.1016/j.ophtha.2014.11.016.
18. Singer M, Sagong M, van Hemert J, et al.Ultra-widefield imaging of the peripheral retinal vasculature in normal subjects [J].Ophthalmology, 2016, 123(5): 1053-1059. DOI:10.1016/ j.Ophtha.2016.01.022.

Chinese Journal of Ocular Fundus Diseases

Application of ultra-wide-field fluorescein angiography and 7 standard field in retinal vein occlusion

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