Objective To observe the fundus fluorescein angiography (FFA) manifestations of pediatric morning glory syndrome (MGS) patients.
Methods Fourteen eyes diagnosed as MGS of 14 patients were studied. Among the 14 cases, there were 7 male and 7 female patients. At the time of FFA, the mean age of the patients was (38.75±33.91) months old, ranging from 5.5 to 128.0 months. Among the 14 eyes, four (28.57%) were associated with persistent hyperplastic primary vitreous; four (28.57%) were associated with retinal detachment with no retinal breaks, and one (7.14%) was associated with peripapillary subretinal exudation. All patients underwent peripapillary laser photocoagulation under general anesthesia first and then FFA with the third generation of wide-angle digital retinal imaging system. The arm-retinal circulation time (A-RCT), numbers of blood vessels on the edges of optic disc of the MGS eyes and the contralateral healthy eyes, retinal vascular morphology, the peripheral avascular area, neovascularization, retinal detachment and other abnormalities were documented. The horizontal and vertical diameters of the optic disc of the affected eyes and the contralateral healthy eyes were measured. To compare the A-RCT, 16 children with normal FFA were selected as control group.
Results The diameters of the vertical and horizontal axis of the affected eyes were as (2.56±0.58) and (2.73±0.60) times of the contralateral healthy eyes respectively. The average A-RCT of the affected eyes and eyes of the control group were (13.25±4.10) and (9.34±2.20) s respectively. The affected eyes had significantly prolonged A-RCT. At early stage, the optic disc and peripapillary areas showed hypo-fluorescence, while the irregular retinochoroidal atrophy area outside of the optic disk manifested as hyper-fluorescence ring. At late stage, optic disc showed hyper-fluorescence. Numbers of blood vessels on the edge of the optic disc of the affected eyes and contralateral healthy eyes were 30.27±4.86 and 15.83±1.95 respectively, the affected eyes had much more vessels than the contralateral healthy eyes. All affected eyes had peripheral retinal non-perfusion areas.
Conclusion FFA examination showed prolonged A-RCT and peripheral retinal non-perfusion areas in the affected MGS eyes.
Citation：
PengJie, ZhangQi, FeiPing. Fundus fluorescein angiography of pediatric morning glory syndrome patients. Chinese Journal of Ocular Fundus Diseases, 2015, 31(4): 355-358. doi: 10.3760/cma.j.issn.1005-1015.2015.04.011
Copy
Copyright © the editorial department of Chinese Journal of Ocular Fundus Diseases of West China Medical Publisher. All rights reserved
| 1. |
Kindler P. Morning glory syndrome: unusual congenital optic disk anomaly[J]. Am J Ophthalmol, 1970, 69(3):376-384.
|
| 2. |
Shapiro MJ, Chow CC, Blair MP, et al. Peripheral nonperfusion and tractional retinal detachment associated with congenital optic nerve anomalies[J]. Ophthalmology, 2013, 120(3):607-615.
|
| 3. |
张琦, 赵培泉, 蔡璇, 等. 家族性渗出性玻璃体视网膜病变的临床特征[J]. 中华眼底病杂志, 2014, 30(4):374-377.
|
| 4. |
Blair MP, Shapiro MJ, Hartnett ME. Fluorescein angiography to estimate normal peripheral retinal nonperfusion in children[J].J AAPOS, 2012, 16(3):234-237.
|
| 5. |
苏龙. 荧光素眼底血管造影的正常表现[M]//李筱荣,张红. 荧光素眼底血管造影手册. 天津:天津科技翻译出版公司,2007:9-20.
|
| 6. |
Hellström A, Wiklund LM, Svensson E. The clinical and morphologic spectrum of optic nerve hypoplasia[J]. J AAPOS, 1999, 3(4):212-220.
|
- 1. Kindler P. Morning glory syndrome: unusual congenital optic disk anomaly[J]. Am J Ophthalmol, 1970, 69(3):376-384.
- 2. Shapiro MJ, Chow CC, Blair MP, et al. Peripheral nonperfusion and tractional retinal detachment associated with congenital optic nerve anomalies[J]. Ophthalmology, 2013, 120(3):607-615.
- 3. 张琦, 赵培泉, 蔡璇, 等. 家族性渗出性玻璃体视网膜病变的临床特征[J]. 中华眼底病杂志, 2014, 30(4):374-377.
- 4. Blair MP, Shapiro MJ, Hartnett ME. Fluorescein angiography to estimate normal peripheral retinal nonperfusion in children[J].J AAPOS, 2012, 16(3):234-237.
- 5. 苏龙. 荧光素眼底血管造影的正常表现[M]//李筱荣,张红. 荧光素眼底血管造影手册. 天津:天津科技翻译出版公司,2007:9-20.
- 6. Hellström A, Wiklund LM, Svensson E. The clinical and morphologic spectrum of optic nerve hypoplasia[J]. J AAPOS, 1999, 3(4):212-220.
1/5
WeChat